When Jane, an aspiring writer, meets filmmaker John Bridges, they both want the same things: to be in love, to live a successful, creative life, and to be happy. When they marry, Jane believes she has found everything she was looking for, including—a few years later—all the attendant joys and labors of motherhood. But it’s not long until Jane finds herself subsumed by John’s ambitions, whims, and ego; in short, she becomes a wife.

Toby Fleishman thought he knew what to expect when he and his wife of almost fifteen years separated: weekends and every other holiday with the kids, some residual bitterness, the occasional moment of tension in their co-parenting negotiations. He could not have predicted that one day, in the middle of his summer of sexual emancipation, Rachel would just drop their two children off at his place and simply not return. He had been working so hard to find equilibrium in his single life. The winds of his optimism, long dormant, had finally begun to pick up. Now this.

The three Blue sisters are exceptional—and exceptionally different. Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London; Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; and Lucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left the family reeling. A year later, as they each navigate grief, addiction and ambition, they find they must return to New York to stop the sale of the apartment they were raised in.

Julia Ames, after a youth marked by upheaval and emotional turbulence, has found herself on the placid plateau of mid-life. But Julia has never navigated the world with the equanimity of her current privileged class. Having nearly derailed herself several times, making desperate bids for the kind of connection that always felt inaccessible to her, she finally feels, at age fifty seven, that she has a firm handle on things. She’s unprepared, though, for what comes next.

With her remarkable insight into the human condition and silences that contain multitudes, Elizabeth Strout returns to the town of Crosby, Maine, and to her beloved cast of characters—Lucy Barton, Olive Kitteridge, Bob Burgess, and more—as they deal with a shocking crime in their midst, fall in love and yet choose to be apart, and grapple with the question, as Lucy Barton puts it, “What does anyone’s life mean?”