Everyone in Hemingway Grove, Illinois, knows David and Marcie Bowers. David owns the local pub. Marcie is a former big-city lawyer who practices family law. When David jumps into Cotton River to save a drowning stranger, he’s celebrated as a hero. His muscled physique, shaved head, and piercing blue eyes are broadcast on every news outlet. For most people, newfound fame is a lifeline. For David Bowers, it’s a death sentence. For Marcie Bowers, it’s a test.

Dr. Brandt Savage is on sabbatical from the University of Chicago. Instead of doing solo fieldwork in anthropology, the gawky, bespectacled PhD finds himself enrolled in a school where he is the sole pupil. His professor, “Meed,” is demanding. She’s also his captor. Savage emerges from their intensive training sessions physically and mentally transformed, but with no idea why he’s been chosen, and how he’ll use his fearsome abilities. Then his first mission with Meed takes them back to her own training ground.

Renée Ballard works the night shift in Hollywood, beginning many investigations but finishing none, as each morning she turns her cases over to day shift detectives. A once up-and-coming detective, she's been given this beat as punishment after filing a sexual harassment complaint against a supervisor. But one night she catches two cases she doesn't want to part with: the brutal beating of a prostitute left for dead in a parking lot and the killing of a young woman in a nightclub shooting. Ballard is determined not to give up at dawn.

Alex Cross is a homicide detective with a Ph.D. in psychology. He works and lives in Southeast D.C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities.

Every day without fail, Travis Devine puts on a cheap suit, grabs his faux-leather briefcase, and boards the 6:20 commuter train to Manhattan, where he works as an entry-level analyst at the city’s most prestigious investment firm. In the mornings, he gazes out the train window at the lavish homes of the uberwealthy, dreaming about joining their ranks. In the evenings, he listens to the fiscal news on his phone, already preparing for the next grueling day in the cutthroat realm of finance. Then one morning Devine’s tedious routine is shattered by an anonymous email: She is dead.