Since childhood Nila Carter has been made to spend every weekend at the family cabin. In her teenage years she believes it to be a prison; as an adult it becomes her sanctuary and means to survive. When a mysterious outbreak occurs in India, Nila's brother, Bobby, a virologist with the CDC, places the family on a precautionary alert to be ready to bug out. Unlike anything he's ever seen, the rabies-like virus is not just deadly; it causes extreme violent behavior in those infected.

Rose Winter has enough problems. With a marriage going down the tubes and a dreaded anniversary party on the horizon, the last thing she needs is the zombie apocalypse. She wanted to get drunk and sing karaoke, not murder her undead neighbors. It’s clear the party’s over, however, now Rose has more problems - a missing husband, an overbearing houseguest, and keeping her family alive.

Sylvie Rossi has the loner thing down pat, with the exception of her best friend, Grace. But when the two are trapped in a hospital during the last gasp of a dying city, alone time is no longer an option. A nurse's offer of sanctuary promises Sylvie the supplies she needs to survive the zombies - it's the coexisting with people that might do her in. Eric Forrest will do whatever it takes to get into the dead city for his sister, including ending up dead himself. He's used to taking risks, but with every mile he travels death looks likelier.

Whether romantic or platonic, changing relationships prove tricky for Rose, Tom, Clara, and Craig—never mind adapting to the new not-so-normal. Being surrounded by the undead is bad enough, but with a tyrant-in-training running their Safe Zone, it’s that much worse.

The morning that the world ends, Katie is getting ready for court and housewife Jenni is taking care of her family. Less than two hours later, they are fleeing for their lives from a zombie horde. Thrown together by circumstance, Jenni and Katie become a powerful zombie-killing partnership, mowing down zombies as they rescue Jenni's stepson, Jason, from an infected campground.