Since childhood Nila Carter has been made to spend every weekend at the family cabin. In her teenage years she believes it to be a prison; as an adult it becomes her sanctuary and means to survive. When a mysterious outbreak occurs in India, Nila's brother, Bobby, a virologist with the CDC, places the family on a precautionary alert to be ready to bug out. Unlike anything he's ever seen, the rabies-like virus is not just deadly; it causes extreme violent behavior in those infected.

Sylvie Rossi has the loner thing down pat, with the exception of her best friend, Grace. But when the two are trapped in a hospital during the last gasp of a dying city, alone time is no longer an option. A nurse's offer of sanctuary promises Sylvie the supplies she needs to survive the zombies - it's the coexisting with people that might do her in. Eric Forrest will do whatever it takes to get into the dead city for his sister, including ending up dead himself. He's used to taking risks, but with every mile he travels death looks likelier.

Rose Winter has enough problems. With a marriage going down the tubes and a dreaded anniversary party on the horizon, the last thing she needs is the zombie apocalypse. She wanted to get drunk and sing karaoke, not murder her undead neighbors. It’s clear the party’s over, however, now Rose has more problems - a missing husband, an overbearing houseguest, and keeping her family alive.

The morning that the world ends, Katie is getting ready for court and housewife Jenni is taking care of her family. Less than two hours later, they are fleeing for their lives from a zombie horde. Thrown together by circumstance, Jenni and Katie become a powerful zombie-killing partnership, mowing down zombies as they rescue Jenni's stepson, Jason, from an infected campground.

Tough-as-nails Dakota Sloane has spent her life running from the past. A man haunted by secrets, Logan Garcia has only one goal: to drink himself into oblivion. When a bomb detonates over Miami, utter anarchy erupts. Dakota knows of a safe house deep in the Everglades, but she needs Logan's help to survive the chaos. But the radiation isn't the only threat. At every turn, deadly foes are determined to stop them. As a diabolical conspiracy emerges, Logan and Dakota must prepare for the fight of their lives against an enemy more powerful than they could ever imagine.