Irina obsessively takes explicit photographs of the average-looking men she persuades to model for her, scouted from the streets of Newcastle. Placed on sabbatical from her dead-end bar job, she is offered an exhibition at a fashionable London gallery, promising to revive her career in the art world and offering an escape from her rut of drugs, alcohol and extreme cinema. The news triggers a self-destructive tailspin, centred around Irina's relationship with her obsessive best friend and a shy young man from her local supermarket who has attracted her attention....

Our narrator should be happy, shouldn't she? She's young, thin, pretty, a recent Columbia graduate; she works an easy job at a hip art gallery and lives in an apartment on the Upper East Side of Manhattan paid for, like the rest of her needs, by her inheritance. But there is a dark and vacuous hole in her heart, and it isn't just the loss of her parents, or the way her Wall Street boyfriend treats her, or her sadomasochistic relationship with her best friend, Reva. It's the year 2000 in a city aglitter with wealth and possibility; what could be so terribly wrong?

Our narrator produces a sound from the piano no one else at the Conservatory can. She employs a technique she learned from her parents—also talented musicians—who fled China in the wake of the Cultural Revolution. But when an accident leaves her parents debilitated, she abandons her future for a job at a high-end beauty and wellness store in New York City.

Rachel is 24, a lapsed Jew who has made calorie restriction her religion. By day, she maintains an illusion of existential control through obsessive food rituals while working as an underling at a Los Angeles talent management agency. Rachel is content to carry on subsisting - until her therapist encourages her to take a 90-day communication detox from her mother, who raised her in the tradition of calorie counting. Rachel soon meets Miriam, a zaftig young Orthodox Jewish woman who works at her favorite frozen yogurt shop and is intent upon feeding her.

Leah is changed. Months earlier, she left for a routine expedition, only this time her submarine sank to the sea floor. When she finally surfaces and returns home, her wife Miri knows that something is wrong. Barely eating and lost in her thoughts, Leah rotates between rooms in their apartment, running the taps morning and night. As Miri searches for answers, desperate to understand what happened below the water, she must face the possibility that the woman she loves is slipping from her grasp.

Having recently moved both herself and her formidable perfume bottle collection into a tiny bungalow in Los Angeles, mid-list author Astrid Dahl finds herself back in the Zoom writer’s group she cofounded, Sapphic Scribes, after an incident that leaves her and her career lightly canceled. But she temporarily forgets all that by throwing herself into a few sexy distractions—like Ivy, a grad student researching 1950s lesbian pulp who smells like metallic orchids, or her new neighbor, Penelope, who smells like patchouli.

Candace Chen, a millennial drone self-sequestered in a Manhattan office tower, is devoted to routine. With the recent passing of her Chinese immigrant parents, she’s had her fill of uncertainty. She’s content just to carry on: She goes to work, troubleshoots the teen-targeted Gemstone Bible, watches movies in a Greenpoint basement with her boyfriend. So Candace barely notices when a plague of biblical proportions sweeps New York.

Greta lives with her friend Sabine in an ancient Dutch farmhouse in Hudson, New York. The house is unrenovated, uninsulated, and full of bees. Greta spends her days transcribing therapy sessions for a sex coach who calls himself Om. She becomes infatuated with his newest client, a repressed married woman she affectionately refers to as Big Swiss.

A year into her dream job at a cutthroat Silicon Valley start-up, Cassie finds herself trapped in a corporate nightmare. Between the long hours, toxic bosses, and unethical projects, she also struggles to reconcile the glittering promise of a city where obscene wealth lives alongside abject poverty and suffering. Ivy League grads complain about the snack selection from a conference room with a view of unhoused people bathing in the bay. Start-up burnouts leap into the paths of commuter trains, and men literally set themselves on fire in the streets.

Gilda, a 20-something, atheist, animal-loving lesbian, cannot stop ruminating about death. Desperate for relief from her panicky mind and alienated from her repressive family, she responds to a flyer for free therapy at a local Catholic church, and finds herself being greeted by Father Jeff, who assumes she’s there for a job interview. Too embarrassed to correct him, Gilda is abruptly hired to replace the recently deceased receptionist Grace.