Sixteen-year old Hazel lives in the Daedalus, a starship that is flying in search of a new world. The ship has been traveling for 500 years, searching for a world to settle in after having to abandon its last world. Everyone on board Daedalus lives a very simple existence in farming villages. The age of machines supplying their needs was lost during a mutiny 500 years ago.

The year is 3326. Nigel Sheldon, one of the founders of the Commonwealth, receives a visit from the Raiel - self-appointed guardians of the Void, the enigmatic construct at the core of the galaxy that threatens the existence of all that lives. The Raiel convince Nigel to participate in a desperate scheme to infiltrate the Void. Once inside, Nigel discovers that humans are not the only life-forms to have been sucked into the Void. The humans trapped there are afflicted by an alien species of biological mimics.

In the distant future, corporations have become sustainable communities with their own militaries, and corporate goals have essentially replaced political ideology. On a youthful, rebellious impulse, Lawrence joined the military of a corporation that he now recognizes to be ruthless and exploitative. His only hope for escape is to earn enough money to buy his place in a better corporation.

The year is 2380. The Intersolar Commonwealth, a sphere of stars some 400 light-years in diameter, contains more than 600 worlds, interconnected by a web of transport "tunnels" known as wormholes. At the farthest edge of the Commonwealth, astronomer Dudley Bose observes the impossible: Over 1,000 light-years away, a star...vanishes. It does not go supernova. It does not collapse into a black hole. It simply disappears.

In the 1800s, a sailing ship crashes off the coast of Norway. In the 1900s, a Zepellin explores an icy canyon in Antarctica. In the far future, a spaceship sets out for an alien artifact. Each excursion goes horribly wrong. And on every journey, Dr. Silas Coade is the physician, but only Silas seems to realize that these events keep repeating themselves. And it's up to him to figure out why and how. And how to stop it all from happening again.