Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

Hannah Martin has an unusual job: she's a professional cuddler. While she has a big heart for her clients, she hasn't found someone special to snuggle up to in her personal life. Winter Sullivan isn't looking for love. She's an aloof workaholic who's built walls of ice around herself. She would rather drive toothpicks under her fingernails than cuddle, and she certainly doesn't want to share her space with anyone. When Winter's estranged father dies, he leaves her one last surprise: she and Hannah, a perfect stranger, will inherit a building together.

Ashley Tanner’s only desire after losing her father to a prescription overdose as a teenager has been to support her working-class family. Now an ambitious lawyer, she’s on the verge of achieving the coveted partnership she’s worked for her entire career. But with her goal in sight, the return of a mysterious woman from Ash’s past puts the promotion at risk and forces her to confront the sacrifices she’s made to win at all costs.

Since A-List actress and Hollywood's sweetheart Wren Acker came out, not only is she at the top of the acting world; she's also crush number one for her queer fanbase. Loving life, loving her job, loving her cat-everything is fantastic. Except that lack of any kind of private life. When a car accident brings her to the ER, the bottom falls out of her world when she realizes that reserved Doctor Taylor, her physician, is Madison Taylor from camp way back when she was a kid. And boy, does Madison still hold a well-earned grudge for how that all ended.

Unemployed academic Caitlyn Taylor comes home to family drama. Her carefree twin Chloe plans to ditch her job to visit a guy she met online. Caitlyn steps in to impersonate Chloe so she won't get fired for skipping town. Unfortunately, this means answering phones for an icy, dismissive boss. Busy college president Ruth Holloway never paid much attention to her mediocre assistant. Suddenly, "Chloe" demonstrates insight into faculty politics and a baffling talent for analytics. And since when has she been so attractive?