Anna McNichol knows how to take charge. Raised by a single mother, she’s worked to ensure her three children have every advantage she didn’t. And while her marriage has its problems, she values commitment and believes in "till death do us part." Now an empty nester, she’s at the peak of her career and ready to seize the opportunity to focus on her future.

Wanted: Midwife/nurse practitioner in Virgin River, population 600. Make a difference against a backdrop of towering California redwoods and crystal clear rivers. Rent-free cabin included. When the recently widowed Melinda Monroe sees this ad, she quickly decides that the remote mountain town of Virgin River might be the perfect place to escape her heartache and to reenergize the nursing career she loves. But her high hopes are dashed within an hour of arriving - the cabin is a dump, the roads are treacherous, and the local doctor wants nothing to do with her.

The Lakey sisters are perfect opposites. After their mother died and their father was lost in grief, Willa had no choice but to raise her sister, Harper, and their brother, Lucas. Then, as an adult, she put her own life on hold to nurse Harper through a terrifying illness. Now that Harper is better and the sisters are living as roommates, Willa has realized her dream of running her own bakery and coffee shop, bringing her special brand of caretaking to the whole Oceanside community.

Michelle Sanderson may appear to be a strong, independent woman, but on the inside, she’s still the wounded girl who fled home years ago. A young army vet, Michelle returns to the quaint Blackberry Island Inn to claim her inheritance and recover from the perils of war. Instead, she finds the owner’s suite occupied by the last person she wants to see. Carly Williams and Michelle were once inseparable, until a shocking betrayal destroyed their friendship. And now Carly is implicated in the financial disaster lurking behind the inn’s cheerful veneer.

Gerri can't decide what's more devastating: learning her rock-solid marriage has big cracks, or the anger she feels as she tries to repair them. Always the anchor for friends and her children, she realizes it's time to look carefully at herself. The journey is more than revealing—it's transforming. Andy has come to believe that a lasting love is out of reach. When she finds herself attracted to a man without any of the qualities that usually appeal to her, she questions everything she thought she wanted in life.