It is the autumn of 1880, and Dr. John Watson has just returned from Afghanistan. Badly injured and desperate to forget a nightmarish expedition that left him doubting his sanity, Watson is close to destitution when he meets the extraordinary Sherlock Holmes, who is investigating a series of deaths in the Shadwell district of London. Several bodies have been found, the victims appearing to have starved to death over the course of several weeks, and yet they were reported alive and well mere days before.

It’s the autumn of 1890, and a spate of bombings has hit London. The newspapers are full of fevered speculation about anarchists, antimonarchists and Fenians. But one man suspects an even more sinister hand behind the violence. Sherlock Holmes believes Professor Moriarty is orchestrating a nationwide campaign of terror, but to what end? At the same time, a bizarrely garbed figure has been spotted on the rooftops and in the grimy back alleys of the capital.

The Cthulhu Mythos is one of the 20th century's most singularly recognizable literary creations. Initially created by H. P. Lovecraft and a group of his amorphous contemporaries (the so-called "Lovecraft Circle"), The Cthulhu Mythos story cycle has taken on a convoluted, cyclopean life of its own. Some of the most prodigious writers of the 20th century, and some of the most astounding writers of the 21st century have planted their seeds in this fertile soil. The Book of Cthulhu harvests the weirdest and most corpulent crop of these modern mythos tales.

London. A snowy December, 1888. Sherlock Holmes, 34, is languishing and back on cocaine after a disastrous Ripper investigation. Watson can neither comfort nor rouse his friend - until a strangely encoded letter arrives from Paris. Mlle La Victoire, a beautiful French cabaret star, writes that her illegitimate son by an English lord has disappeared, and she has been attacked in the streets of Montmartre.

Sherlock Holmes is the greatest detective in literary history. For the first time since the death of Sir Arthur Conan Doyle, a new Holmes story has been sanctioned by his estate, whetting the appetites of fans everywhere. Information about the book will be revealed as deliberately as Holmes himself would unravel a knotty case, but bestselling novelist and Holmes expert Anthony Horowitz is sure to bring a compelling, atmospheric story to life.