It is the thirty-second millennium and the Imperium is at peace. The Traitor Legions of Chaos are but a distant memory and the many alien races that have long plagued mankind are held in check by the Space Marines. But an ork invasion of unparalleled scale throws the Imperium into disarray. As worlds burn and renowned Space Marine Chapters are destroyed, can the Imperium pull together to defeat the Beast?

The Inquisition moves amongst mankind like an avenging shadow, striking down the enemies of humanity with uncompromising ruthlessness. When he finally corners an old foe, Inquisitor Gregor Eisenhorn is drawn into a sinister conspiracy. As events unfold and he gathers allies - and enemies - Eisenhorn faces a vast interstellar cabal and the dark power of daemons, all racing to recover an arcane text of abominable power: an ancient tome known as the Necroteuch.

Supreme Grand Master Azrael summons Lazarus and his Fifth Company to honour an old debt on the Knight world of Reis – a planet upon which the warp has set its hungry gaze. But Lazarus is not so sure Reis wants to be saved – its Knights are long lost, its governance is dogged by political strife, and internecine conflict hampers the world’s defence against an ancient evil. ­An evil which, like Lazarus himself, refuses to die.

The Night Lords were once among the most potent forces of the Imperium, Space Marines who used fear itself as their weapon. Now, cast adrift from the Emperor's light and hunted as heretics after their monstrous betrayal, the Night Lords clad themselves in symbols of death and fight the Long War, bringing pain and terror to all who worship the corpse-god of Terra. A summons from Warmaster Abaddon sends these rebels on a dangerous journey that leads inexorably to a conflict with the Emperor's chosen warriors, the Blood Angels.

A great darkness has befallen the galaxy, and the armies of Chaos are rampant. To survive, humanity must retaliate and take back what they have lost. By the will of the reborn primarch, Roboute Guilliman, is the Indomitus Crusade launched - a military undertaking that eclipses all others in known history. From the Throneworld of Terra does the Avenging Son hurl his fleets, their mission the very salvation of mankind.