Dante is Chapter Master of one of the noblest but most troubled Chapters of Space Marines in the Imperium: the Blood Angels. From the time of his birth in the rad-scarred wastes of Baal Secundus, he was destined for glory and strife. From his apotheosis to Scout, to the hive cities of Armageddon and the alien menace of the Cryptus system, Dante has waged war against all the enemies of the Imperium. He has witnessed the divine, and struggled against the darkness within all sons of Sanguinius.

The galaxy is in flames. Chaos is in the ascendant across the stars. The Great Rift has split the holdings of the Imperium in twain, isolating entire sectors from the light of Holy Terra. But all hope is not lost. The Primarch Roboute Guilliman has returned from deathless sleep and appointed Commander Dante, lord of the Blood Angels, as Regent and Warden of the newly dubbed Imperium Nihilus. In the Baal system, the shattered holding of the Chapter is being rebuilt, and Dante plans the greatest campaign of his long life, to retake half an empire.

Fell times have come to the galaxy. Cadia has fallen, destroyed by the onslaught of Chaos. A Great Rift in the warp has opened, and from its depths spew daemons and the horrors of Old Night. But all hope is not lost… A hero, long absent, has returned, and with him comes the wrath of the Ultramarines reborn. Roboute Guilliman has arisen to lead the Imperium out of darkness on a crusade the likes of which has not been seen since the fabled days of the Emperor. But never before have the forces of Ruin amassed in such numbers, and nowhere is safe from despoliation.

For Ianthe, war is all too familiar. A former soldier in the Astra Militarum, she now serves Inquisitor Covenant as an agent of the Throne. Her first mission sees her investigating a cult called the Children of Eternity. Falling foul of the local Enforcers, Ianthe soon learns that war in the shadows is seldom straightforward and that the local, angry law-keepers are the least of her troubles.

Belisarius Cawl, Archmagos Dominus of the Adeptus Mechanicus, is the most brilliant mind alive. For 10,000 years he has furthered the cause of mankind, working under the aegis of the Emperor and Lord Commander Roboute Guilliman to prevent the inexorable march of the alien and the traitor. Many call him heretic, but all must recognise the magnitude of his achievements, for who else but he was entrusted to create a new generation of Space Marines?

Two centuries ago, the Imperium of Man and the upstart Tau Empire fought to a standstill in the Damocles Gulf. Now, as the 41st millennium draws to a close, the tau have returned. As the world of Agrellan falls under attack, the White Scars and Raven Guard rush to its defence, but with the skilled Commander Shadowsun leading the alien forces, the Space Marines and their allies are hard pressed. Kor'sarro Khan, Huntmaster of the White Scars, swears that he will win the day in the most direct way possible – by taking Shadowsun's head.

Supreme Grand Master Azrael summons Lazarus and his Fifth Company to honour an old debt on the Knight world of Reis – a planet upon which the warp has set its hungry gaze. But Lazarus is not so sure Reis wants to be saved – its Knights are long lost, its governance is dogged by political strife, and internecine conflict hampers the world’s defence against an ancient evil. ­An evil which, like Lazarus himself, refuses to die.

Before the being called the Emperor revealed himself, before the rise of the aeldari, before the necrontyr traded their flesh for immortal metal, the world was born in violence. Even when they inhabited bodies of flesh, Trazyn the Infinite and Orikan the Diviner were polar opposites. Trazyn, a collector of historical oddities, presides over a gallery full of the most dangerous artefacts - and people - of the galactic past. Orikan, a chronomancer without peer, draws zodiacs that predict and manipulate the future.

Exile to the miserable world of Sedh, the disgraced Necron Lord Oltyx is consumed with bitterness. Once heir to the throne of a dynasty, he now commands nothing but a dwindling garrison of warriors, in a never-ending struggle against Ork invaders. Oltyx can think of nothing but the prospect of vengeance against his betrayers, and the reclamation of his birthright. But the Orks are merely the harbingers of a truly unstoppable force. Unless Oltyx acts to save his dynasty, revenge will win him only ashes.

He is known by many names - Clonelord, Manflayer, Primogenitor. He is the epitome of deceit and perversion, and feared by man and monster alike. Once the Chief Apothecary of the Emperor's Children, the madman known as Fabius Bile possesses a knowledge of genetic manipulation second to none.

The shrine world of Divinatus Prime has become lost to the light of the Astronomican, and no ship can piece its veil. Only the Lord of Death himself, Blood Angels Chief Librarian Mephiston, has any hope of discerning the fate of this once pious world. After enacting a powerful blood ritual, Mephiston and an honour guard of his fellow Blood Angels reach the stricken shrine world to find it seized by religious civil war. Each faction fights for dominance of a potent artefact, the Blade Petrific, said to be wrought by the Emperor Himself.

The Cadian Gate is broken, and the Imperium is riven in two. The might of the Traitor Legions, kept shackled for millennia behind walls of iron and sorcery, has been unleashed on a darkening galaxy. Among those seeking vengeance on the Corpse Emperor’s faltering realm are the Death Guard, once proud crusaders of the Legiones Astartes, now debased creatures of terror and contagion.

A great darkness has befallen the galaxy, and the armies of Chaos are rampant. To survive, humanity must retaliate and take back what they have lost. By the will of the reborn primarch, Roboute Guilliman, is the Indomitus Crusade launched - a military undertaking that eclipses all others in known history. From the Throneworld of Terra does the Avenging Son hurl his fleets, their mission the very salvation of mankind.

On the prison world of Zartak, darkness has fallen on arbitrators and inmates alike. The Night Lords have come, bringing with them the shadow of fear and pain. But these monsters are not the only ones with an interest in Zartak. From the void, running on silent, another fleet emerges. These Space Marine warriors are grey-clad and white-faced, and their eyes are as black as the Outer Dark – the savage Carcharodon Astra.

The Custodian Guard have stood watch over the Emperor's Palace on Terra since the foundation of the Imperium. Charged with protecting the Master of Mankind from all threats, within and without, their fearsome resolve is renowned throughout the galaxy, and their golden armour is the last thing that a would-be assassin or saboteur will ever see.