Evan Smoak is a man with skills, resources, and a personal mission to help those with nowhere else to turn. He’s also a man with a dangerous past. Chosen as a child, he was raised and trained as an Orphan, an off-the-books black box program designed to create the perfect deniable intelligence asset: An assassin. Evan was Orphan X - until he broke with the program and used everything he learned to disappear. But now someone is on his tail.

Joey Morales was the last recruit of the government's full black operation, the Orphan Program. Trained to be an assassin until she washed out, she was rescued by Evan Smoak, the former agent known as Orphan X. Now Joey, a world-class hacker, starts training for one of her biggest challenges yet: having a normal life. Still a teenager, she discovers she loves music as much as hacking, if not more so. But as she carves out a space for herself, the one thing missing is a family to support her endeavors.

Tim Rackley, a deputy U.S. marshal, watches helplessly as his daughter's killer walks free on a legal technicality. He is suddenly forced to explore his own deadly options, a quest that leads him into the welcoming fold of "The Commission".

The scion of an old-money San Francisco family, Daniel Brasher left his well-paying, respectable money-manager position to marry his community organizer wife and work at a job he loves, leading group counseling sessions with recently paroled violent offenders. One night he finds an envelope - one intended for someone else that was placed in his office mailbox by accident. Inside is an unsigned piece of paper, a handwritten note that says, "Admit what you've done or you will bleed for it."

Nate Overbay, a former soldier suffering from PTSD and ALS, goes to an 11th-floor bank and climbs out the bathroom window onto the ledge, ready to end it all. But as he’s steeling himself to jump, a crew of gunmen bursts into the bank and begins viciously shooting employees and customers. With nothing to lose, Nate climbs back inside, confronts the robbers, and with his military training, starts taking them out, one by one. The last man standing leaves Nate with a cryptic warning: “He will make you pay in ways you can’t imagine.” Soon enough, Nate learns what this means.