Every day without fail, Travis Devine puts on a cheap suit, grabs his faux-leather briefcase, and boards the 6:20 commuter train to Manhattan, where he works as an entry-level analyst at the city’s most prestigious investment firm. In the mornings, he gazes out the train window at the lavish homes of the uberwealthy, dreaming about joining their ranks. In the evenings, he listens to the fiscal news on his phone, already preparing for the next grueling day in the cutthroat realm of finance. Then one morning Devine’s tedious routine is shattered by an anonymous email: She is dead.

Renée Ballard works the night shift in Hollywood, beginning many investigations but finishing none, as each morning she turns her cases over to day shift detectives. A once up-and-coming detective, she's been given this beat as punishment after filing a sexual harassment complaint against a supervisor. But one night she catches two cases she doesn't want to part with: the brutal beating of a prostitute left for dead in a parking lot and the killing of a young woman in a nightclub shooting. Ballard is determined not to give up at dawn.

Four young women have been found murdered—tortured and strangled in their own beds—all victims of the same brilliant monster. Using a skilled hand and the latest technology in forensic medicine, Kay Scarpetta begins the process of gathering the microscopic clues the latest battered body has to give.

Eve Dallas is a New York police lieutenant hunting for a ruthless killer. In over ten years on the force, she’s seen it all - and knows her survival depends on her instincts. And she’s going against every warning telling her not to get involved with Roarke, an Irish billionaire - and a suspect in Eve’s murder investigation.

The "maddog" murderer who is terrorizing the Twin Cities is two things: insane and extremely intelligent. He kills for the pleasure of it and thoroughly enjoys placing elaborate obstacles to keep police befuddled. Each clever move he makes is another point of pride. But when the brilliant Lieutenant Lucas Davenport, a dedicated cop and a serial killer's worst nightmare, is brought in to take up the investigation, the maddog suddenly has an adversary worthy of his genius.