The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

In 1967, four female scientists worked together to build the world’s first time machine. But just as they are about to debut their creation, one of them suffers a breakdown, putting the whole project - and future of time travel - in jeopardy. To protect their invention, one member is exiled from the team - erasing her contributions from history. Fifty years later, time travel is a big business. Twenty-something Ruby Rebello knows her beloved grandmother Granny Bee was one of the pioneers, though no one will tell her more.

In 1760, Deborah Samson is born to Puritan parents in Plympton, Massachusetts. When her father abandons the family and her mother is unable to support them, Deborah is bound out as an indentured servant. From that moment on, she yearns for a life of liberation and adventure. Twenty years later, as the American colonies begin to buckle in their battle for independence, Deborah, impassioned by the cause, disguises herself as a soldier and enlists in the Continental Army.

Kabul, 1978: The daughter of a prominent family, Sitara Zamani lives a privileged life in Afghanistan’s thriving cosmopolitan capital. The 1970s are a time of remarkable promise under the leadership of people like Sardar Daoud, Afghanistan’s progressive president, and Sitara’s beloved father, his right-hand man. But the ten-year-old Sitara’s world is shattered when communists stage a coup, assassinating the president and Sitara’s entire family. Only she survives.

As children, Eva Rosselli and Angelo Bianco were raised like family but divided by circumstance and religion. As the years go by, the two find themselves falling in love. But the church calls to Angelo and, despite his deep feelings for Eva, he chooses the priesthood. Now, more than a decade later, Angelo is a Catholic priest and Eva is a woman with nowhere to turn. With the Gestapo closing in, Angelo hides Eva within the walls of a convent.

Moments after Lisbeth is born, she’s taken from her mother and handed over to an enslaved wet nurse, Mattie, a young mother separated from her own infant son in order to care for her tiny charge. Thus begins an intense relationship that will shape both of their lives for decades to come. Though Lisbeth leads a life of privilege, she finds nothing but loneliness in the company of her overwhelmed mother and her distant, slave-owning father.

August 1939: London is dismal under the weight of impending war with Germany as Hitler’s forces continue to sweep across Europe. Into this uncertain maelstrom steps Grace Bennett, young and ready for a fresh start in the bustling city streets she’s always dreamed of - and miles away from her troubled past in the countryside. With aspirations of working at a department store, Grace never imagined she’d wind up employed at Primrose Hill, an offbeat bookshop nestled in the heart of the city - after all, she’s never been much of a reader.

Southern China, 1923. Desperate to secure her future, Mei Ling’s parents arrange a marriage to a widower in California. To enter the country, she must pretend to be her husband’s first wife - a paper wife. On the perilous voyage, Mei Ling takes an orphan girl named Siew under her wing. Dreams of a better life in America give Mei Ling the strength to endure the treacherous journey and detainment on Angel Island. But when she finally reaches San Francisco, she’s met with a surprise. Her husband, Chinn Kai Li, is a houseboy, not the successful merchant he led her to believe.

A middle-aged man returns to his childhood home to attend a funeral. He is drawn to the farm at the end of the road, where, when he was seven, he encountered a most remarkable girl, Lettie Hempstock. Forty years earlier, a man committed suicide in a stolen car at this farm at the end of the road. Like a fuse on a firework, his death lit a touchpaper and resonated in unimaginable ways. The darkness was unleashed, something scary and thoroughly incomprehensible to a little boy. And Lettie - magical, comforting, wise beyond her years - promised to protect him, no matter what.

The Poisonwood Bible is a story told by the wife and four daughters of Nathan Price, a fierce, evangelical Baptist who takes his family and mission to the Belgian Congo in 1959. They carry with them everything they believe they will need from home, but soon find that all of it - from garden seeds to Scripture - is calamitously transformed on African soil. What follows is a suspenseful epic of one family’s tragic undoing and remarkable reconstruction over the course of three decades in postcolonial Africa.