Irina obsessively takes explicit photographs of the average-looking men she persuades to model for her, scouted from the streets of Newcastle. Placed on sabbatical from her dead-end bar job, she is offered an exhibition at a fashionable London gallery, promising to revive her career in the art world and offering an escape from her rut of drugs, alcohol and extreme cinema. The news triggers a self-destructive tailspin, centred around Irina's relationship with her obsessive best friend and a shy young man from her local supermarket who has attracted her attention....

Greta lives with her friend Sabine in an ancient Dutch farmhouse in Hudson, New York. The house is unrenovated, uninsulated, and full of bees. Greta spends her days transcribing therapy sessions for a sex coach who calls himself Om. She becomes infatuated with his newest client, a repressed married woman she affectionately refers to as Big Swiss.

Samantha Heather Mackey couldn't be more of an outsider in her small, highly selective MFA program at New England's Warren University. A scholarship student who prefers the company of her dark imagination to that of most people, she is utterly repelled by the rest of her fiction writing cohort—a clique of unbearably twee rich girls who call each other "Bunny", and seem to move and speak as one. But everything changes when Samantha receives an invitation to the Bunnies' fabled "Smut Salon"....

Twenty-four-year-old British painter Cleo has escaped from England to New York and is still finding her place in the sleepless city when, a few months before her student visa ends, she meets Frank. Twenty years older and a self-made success, Frank’s life is full of all the excesses Cleo’s lacks. He offers her the chance to be happy, the freedom to paint and the opportunity to apply for a green card. But their impulsive marriage irreversibly changes both their lives and the lives of those close to them, in ways they never could’ve predicted.

Lucy has been writing her dissertation on Sappho for nine years when she and her boyfriend break up in a dramatic flameout. After she bottoms out in Phoenix, her sister in Los Angeles insists Lucy dog-sit for the summer. Annika's home is a gorgeous glass cube on Venice Beach, but Lucy can find little relief from her anxiety - not in the Greek chorus of women in her love addiction therapy group, not in her frequent Tinder excursions, not even in Dominic the foxhound's easy affection.

Rachel is 24, a lapsed Jew who has made calorie restriction her religion. By day, she maintains an illusion of existential control through obsessive food rituals while working as an underling at a Los Angeles talent management agency. Rachel is content to carry on subsisting - until her therapist encourages her to take a 90-day communication detox from her mother, who raised her in the tradition of calorie counting. Rachel soon meets Miriam, a zaftig young Orthodox Jewish woman who works at her favorite frozen yogurt shop and is intent upon feeding her.

A woman arrives alone at a Best Western seeking respite from an emptiness that plagues her. She has fled to the California high desert to escape a cloud of sorrow—for both her father in the ICU and a husband whose illness is worsening. What the motel provides, however, is not peace but a path discovered on a nearby hike. Out along the sun-scorched trail, the narrator encounters a towering cactus whose size and shape mean it should not exist in California. Yet the cactus is there, with a gash through its side that beckons like a familiar door.

Little Marek, the abused and delusional son of the village shepherd, believes his mother died giving birth to him. One of Marek’s few consola­tions is his enduring bond with the blind village midwife, Ina, who suckled him when he was a baby. For some people, Ina’s ability to receive trans­missions of sacred knowledge from the natural world is a godsend. For others, Ina’s home in the woods is a godless place.

Remy and Alicia, a couple of insecure service workers, are not particularly happy together. But they are bound by a shared obsession with Jen, a beautiful former coworker of Remy’s who now seems to be following her bliss as a globe-trotting jewelry designer. In and outside the bedroom, Remy and Alicia's entire relationship revolves around fantasies of Jen, whose every Instagram caption, outfit, and new age mantra they know by heart. Imagine their confused excitement when they run into Jen, in the flesh, and she invites them on a surfing trip to the Hamptons.

Our narrator should be happy, shouldn't she? She's young, thin, pretty, a recent Columbia graduate; she works an easy job at a hip art gallery and lives in an apartment on the Upper East Side of Manhattan paid for, like the rest of her needs, by her inheritance. But there is a dark and vacuous hole in her heart, and it isn't just the loss of her parents, or the way her Wall Street boyfriend treats her, or her sadomasochistic relationship with her best friend, Reva. It's the year 2000 in a city aglitter with wealth and possibility; what could be so terribly wrong?