Thomas Austin was once a prominent NYPD detective, known for locking up a psychopathic serial killer dubbed "The Holiday Baby Butcher". Now retired in a small beach town in the Pacific Northwest, Austin runs a little café, trying to overcome the loss of his wife, a DA who was gunned down only one year ago.

Across the Pacific Northwest, a twisted killer stalks victims representing ancient archetypes: The Ruler. The Warrior. The Scholar. The Priest. Four are dead, leaving FBI investigators puzzled by the macabre, color-coded shrines the killer left behind. And clues now point to a fifth victim.

When the chief suspect in the notorious "peekaboo cop killer" case blew himself up, almost taking lead investigator DCI Duncan Bone with him, the psychologically damaged detective thought his days on the force were over. But, when another PC is abducted and murdered in the same deranged peekaboo fashion, Bone is persuaded to return to lead the new investigation.

Quint Adler is a small town crime reporter with bigger aspirations. Stuck in a hospital bed on his 40th birthday, he overhears a conversation that arouses his suspicions. Sensing an opportunity, Quint starts his own investigation, bypassing local law enforcement in the process. His inquiries lead him to the scene of a savage murder. And then a second one, even more barbaric in nature.

Four young women have been found murdered—tortured and strangled in their own beds—all victims of the same brilliant monster. Using a skilled hand and the latest technology in forensic medicine, Kay Scarpetta begins the process of gathering the microscopic clues the latest battered body has to give.