From the bestselling author of Station Eleven and Sea of Tranquility—when Lilia Albert was a child, her father appeared on the doorstep of her mother's house and took her away. Now, haunted by an inability to remember much about her early childhood, Lilia moves restlessly from city to city, abandoning lovers and eluding the private detective who has dedicated a career to following close behind.

Gavin Sasaki was a promising young journalist in New York City until the day he was fired for plagiarism. The last thing he wants is to sell foreclosed real estate for his sister Eilo's company in their Florida hometown, but he's in no position to refuse her job offer. Plus, there's another reason to go home: Eilo recently met a 10-year-old girl who looks very much like Gavin and has the same last name as his high-school girlfriend, Anna, who left town abruptly after graduation.

Kirsten Raymonde will never forget the night Arthur Leander, the famous Hollywood actor, had a heart attack on stage during a production of King Lear. That was the night when a devastating flu pandemic arrived in the city, and within weeks, civilization as we know it came to an end.

Florida is slipping away. As devastating weather patterns and rising sea levels wreak gradual havoc on the state’s infrastructure, a powerful hurricane approaches a small town on the southeastern coast. Kirby Lowe, an electrical line worker, his pregnant wife, Frida, and their two sons, Flip and Lucas, prepare for the worst. When the boys go missing just before the hurricane hits, Kirby heads out into the high winds in search of his children. Left alone, Frida goes into premature labor and gives birth to an unusual child, Wanda, whom she names after the catastrophic storm.

In 2030, a grieving archeologist arrives in the Arctic Circle to continue the work of his recently deceased daughter at the Batagaika Crater, where researchers are studying long-buried secrets now revealed in melting permafrost, including the perfectly preserved remains of a girl who appears to have died of an ancient virus. Once unleashed, the Arctic plague will reshape life on Earth for generations to come, quickly traversing the globe, forcing humanity to devise a myriad of moving and inventive ways to embrace possibility in the face of tragedy.