On a warm summer morning in North Carthage, Missouri, it is Nick and Amy Dunne’s fifth wedding anniversary. Presents are being wrapped and reservations are being made when Nick’s clever and beautiful wife disappears. Husband-of-the-Year Nick isn’t doing himself any favors with cringe-worthy daydreams about the slope and shape of his wife’s head, but passages from Amy's diary reveal the alpha-girl perfectionist could have put anyone dangerously on edge.

Now reduced to a schoolyard chant, the Hope family murders shocked the Maine coast one bloody night in 1929. While most people assume seventeen-year-old Lenora was responsible, the police were never able to prove it. Other than her denial after the killings, she has never spoken publicly about that night, nor has she set foot outside Hope’s End, the cliffside mansion where the massacre occurred. It’s now 1983, and home-health aide Kit McDeere arrives at a decaying Hope’s End to care for Lenora after her previous nurse fled in the middle of the night.

As a child, Natsuki doesn’t fit into her family. Her parents favor her sister, and her best friend is a plush toy hedgehog named Piyyut who has explained to her that he has come from the planet Popinpobopia on a special quest to help her save the Earth.

Working at the local processing plant, Marcos is in the business of slaughtering humans - though no one calls them that anymore. His wife has left him, his father is sinking into dementia, and Marcos tries not to think too hard about how he makes a living. After all, it happened so quickly. First, it was reported that an infectious virus has made all animal meat poisonous to humans. Then governments initiated the "Transition". Now, eating human meat - "special meat" - is legal. Marcos tries to stick to numbers, consignments, processing.

In a boarded-up house on a dead-end street at the edge of the wild Washington woods lives a family of three. A teenage girl who isn’t allowed outside, not after last time. A man who drinks alone in front of his TV, trying to ignore the gaps in his memory. And a house cat who loves napping and reading the Bible. An unspeakable secret binds them together, but when a new neighbor moves in next door, what is buried out among the birch trees may come back to haunt them all.