Nearly three million people worldwide are living with multiple sclerosis (MS), affecting individuals from diverse geographical, ethnic, racial, and socio-economic backgrounds. This diversity raises important questions about how these factors may influence the experiences and outcomes of those with MS, as well as whether research studies and clinical trials have sufficiently addressed this variability. To answer these questions and more, host Brett Drummond of MSTranslate speaks with two leading researchers in this field: Dr. Léorah Freeman, assistant professor at the Dell Medical School Department of Neurology, The University of Texas at Austin; and Dr. Lilyana Amezcua, Associate Professor of Clinical Neurology at the University of Southern California's Keck School of Medicine.

While paediatric onset multiple sclerosis is relatively rare, it presents unique challenges. Extensive research efforts are taking place around the world to better understand the disease mechanism of paediatric MS and the similarities and differences that exist with adult onset MS to help determine the best treatment options for children and adolescents. In this episode, host Brett Drummond of MSTranslate explores the topic with Dr. Yael Hacohen of Great Ormond Street Hospital for Children and UCL Institute of Neurology in the UK and Dr. Thaís Armangué of SJD Barcelona Children's Hospital in Spain.

If you talk to someone living with MS about their journey, one of the first things they will tell you is that they knew something was wrong long before they received their diagnosis. While this anecdotal evidence has been commonly discussed, it was only relatively recently that the research world has started to investigate this concept. Through this work, the idea of an MS prodrome has been studied, with potential implications for early diagnosis and treatment. Host Brett Drummond of MSTranslate speaks with Prof. Helen Tremlett of the University of British Columbia, a leading expert in recognising and investigating the MS prodrome.