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Lawrence Weschler sets Oliver Sacks' brilliant table talk and extravagant personality in vivid relief, casting himself as a beanpole Sancho to Sacks' capacious Quixote. We see Sacks rowing and ranting and caring deeply; composing the essays that would form The Man Who Mistook His Wife for a Hat; recalling his turbulent drug-fueled younger days; helping his patients and exhausting his friends; and waging intellectual war against a medical and scientific establishment that failed to address his greatest concern: the spontaneous specificity of the individual human soul.

For film aficionados, Walter Murch is legendary - a three-time Academy Award winner, arguably the most admired sound and film editor in the world for his work on Apocalypse Now, The Godfather trilogy, The English Patient, and many others. Outside of the studio, his mind is wide-ranging; his passion, pursued for several decades, has been astrophysics, in particular the rehabilitation of Titius-Bode, a long-discredited 18th century theory regarding the patterns by which planets and moons array themselves in gravitational systems across the universe.