One of the main ways of controlling malaria is to reduce mosquito populations through insecticides. But the mosquitoes are developing resistance, making most insecticides less effective. What if the answer lies beneath our feet?

Transcript

One of the main ways of controlling malaria is to reduce mosquito populations through insecticides. But the mosquitoes are developing resistance, making most insecticides less effective. We need new vector control interventions – what if the answer lies beneath our feet? Researchers from the Dimopoulos Group at the Johns Hopkins Malaria Research Institute have turned to an unexpected source of inspiration—soil. They’ve produced a natural biopesticide, derived from a type of bacteria found in soil called Chromobacterium. When you deliver this biopesticide through a sugar bait – which lures the mosquitoes to feed on it – it kills the mosquitoes, regardless of their resistance to insecticides. Additionally, at non-lethal doses, Chromobacterium can enhance the effectiveness of other insecticides, acting as a synergist, as well as making mosquitoes incapable of finding a human to feed on. These findings were first demonstrated in the lab, but have now been confirmed in enclosed field trials in Burkina Faso. It's hoped that this naturally-occurring insecticide could support vector control efforts to curb disease transmission.

Source

Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes (Science)

About The Podcast

The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.