It's America in 1962. Slavery is legal once again. The few Jews who still survive hide under assumed names. In San Francisco, the I Ching is as common as the Yellow Pages. All because some twenty years earlier the United States lost a war - and is now occupied by Nazi Germany and Japan.

Glen Runciter runs a lucrative business - deploying his teams of anti-psychics to corporate clients who want privacy and security from psychic spies. But when he and his top team are ambushed by a rival, he is gravely injured and placed in "half-life," a dreamlike state of suspended animation. Soon, though, the surviving members of the team begin experiencing some strange phenomena, such as Runciter's face appearing on coins and the world seeming to move backward in time.

When catastrophic overpopulation threatens Earth, one company offers to teleport citizens to Whale’s Mouth, an allegedly pristine new home for happy and industrious émigrés. But there is one problem: the teleportation machine works in only one direction. When Rachmael ben Applebaum discovers that some of the footage of happy settlers may have been faked, he sets out on an 18-year journey to see if anyone wants to come back.

For years, the third moon in the Alphane system was used as a psychiatric hospital. But when war broke out between Earth and the Alphanes, the hospital was left unguarded and the inmates set up their own society, made up of competing factions based on their particular mental illnesses. When Earth sends a delegation to take back the colony, they find enclaves of depressives, schizophrenics, paranoiacs, and others uniting to repel what they see as a foreign invasion.

Bob Arctor is a dealer of the lethally addictive drug Substance D. Fred is the police agent assigned to tail and eventually bust him. To do so, Fred takes on the identity of a drug dealer named Bob Arctor. And since Substance D, which Arctor takes in massive doses, gradually splits the user's brain into two distinct, combative entities, Fred doesn't realize he is narcing on himself.