Recently engaged and deeply ensconced in her third year of surgical residency in Chicago, Emily Hartford gets a shock when she is called home to Freeport, Michigan, the small town she fled a decade ago after the death of her mother. Her estranged father, the local medical examiner, has had a massive heart attack. At the hospital, she finds her father in near total denial of the seriousness of his condition. He insists that the best thing Emily can do to help him is to take on the autopsy of a senator's teen daughter whose sudden, unexplained death has just rocked the sleepy town.

July 1989, in a sleepy Michigan town, high school grad Nina Laramie heads out with her friends and is never seen alive again. Months later, her skeleton is found near a remote party spot in the forest. The ME determines Nina has been brutally raped and bludgeoned to death. Fear and anger ripple through this tight-knit community when the case goes cold. Thirty years later, Riley St. James, a Detroit PD assigned to Nina’s case, is determined to get her first big cold case win despite having a similar past to the victim.

When a man is shot in the head, Bree Taggert and her new partner, veteran detective Dana Romano, respond to the call. They break the news to the victim’s ex-wife and learn the estranged couple’s five-year-old daughter was supposed to have been with him. What starts as a murder investigation quickly morphs into a desperate search for a missing child. The case stirs memories of Bree’s own traumatizing childhood. To find the little girl, Bree will have to relive her own terrifying past.

Alex Cross is a homicide detective with a Ph.D. in psychology. He works and lives in Southeast D.C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities.

Investigative journalist Laura Chambers is back in her tiny hometown of Hillsborough, North Carolina, the one place she swore never to return. Fired from The Boston Globe, her career in shambles, she reluctantly takes a job with the local paper. The work is simple, unimportant, and worst of all, boring - at least until a missing girl turns up dead, the body impeccably clean, dressed to be the picture of innocence. Years earlier, 10-year-old Patty Finch left home and never made it back. But for the people of Hillsborough, Patty was just the beginning.