Aging Herb’s charmed life with his dear wife, Susan, in their Key West house is coming undone. Susan now needs constant care, and Herb is in denial about his own ailing health. The one bright spot is the arrival of an endlessly optimistic manicurist calling herself Renee. She sings to Susan during manicures, gets her to paint, and brings her a sense of contentment. But then Herb and Susan’s adult children arrive to stage an intervention on their stubborn, independent father, and as a consequence, Renee’s gig with Susan—and her grand plans for her own life—start to unravel as well.

Born in a country that has repeatedly traumatized her and her loved ones, Maya Wiley grew up in a household that prioritized activism, hope, and resilience above all else. This attitude landed her father on President Nixon’s enemies list as her mother organized third-party political platforms. Still, they modeled hope for their children. In the decades since, she has borne witness as presidents and political figures used racism and fascism to gain power, and as cities have again and again elected white men, effectively shutting out people of color and women from having a political voice.

Al Ward lives on an isolated mining claim in the high desert of central Nevada fifty miles from the nearest town. A grizzled man in his sixties, he survives on canned soup, instant coffee, and memories of his ex-wife, friends and family he’s lost, and his life as a touring musician. Hampered by insomnia, bouts of anxiety, and a chronic lethargy that keeps him from moving back to town, Al finds himself teetering on the edge of madness and running out of reasons to go on—until a horse arrives on his doorstep: nameless, blind, and utterly helpless.

A delivery driver finds himself inside a world occupied by characters from unfinished novels and must accept he is not real. But the world around him doesn’t feel right, and when he starts asking questions, the authorities soon take extreme measures to stop him finding the truth about Fiction Land.

The women of the Cohen family are in crisis. Triggered by the death of their patriarch, Rudy, the glue that held them all together, everyone’s lives soon take a dramatic turn. Shelly, the younger of the two Cohen sisters, runs off to the West Coast to immerse herself in the emerging (and lucrative) world of technology. Her sister, Nancy, gets married at the age of twenty-one to a traveling salesman with a shadowy lifestyle, while their mother, Frieda, hurls herself into a boozy, troubled existence in Miami, trying to forget the past even as it haunts her.

In the summer of 1974 a heatwave blankets Boston and Mary Pat Fennessey is trying to stay one step ahead of the bill collectors. Mary Pat has lived her entire life in the projects of “Southie,” the Irish American enclave that stubbornly adheres to tradition and stands proudly apart. One night Mary Pat’s teenage daughter Jules stays out late and doesn’t come home. That same evening, a young Black man is found dead, struck by a subway train under mysterious circumstances. Mary Pat, propelled by a desperate search for her daughter, begins turning over stones best left untouched.

Investigative crime journalist Signe Gates’s life became a nightmare the day she was kidnapped and drugged. After forty-eight missing hours, she woke to a blur of unsettling memories and a warning from her unknown abductors: tell anyone what happened and they’ll die. They’ve already proved they will deliver on that threat. For two years, Signe has been haunted by what she knows she did and terrified of what else could be buried in her memories.

For years, there have been whispers that, before his death, Van Gogh completed a final self-portrait. Curators and art historians have savored this rumor, hoping it could illuminate some of the troubled artist's many secrets, but even they have to concede that the missing painting is likely lost forever. But when Luke Perrone, artist and great-grandson of the man who stole the Mona Lisa, and Alexis Verde, daughter of a notorious art thief, discover what may be the missing portrait, they are drawn into a most epic art puzzles.

Writer Carrie Colts hopes a move to Montauk will be a rejuvenating change of pace for her family. The last thing she expects to see is her former college roommate on her doorstep. Newly widowed, and with a daughter of her own, Maya would love to reconnect. As a gesture to an old friend in mourning, Carrie extends an invitation to stay. Just for a few days. After all, there are reasons that Carrie and Maya are estranged.

Traumatised by the death of a child in her care, top London paediatrician Claire seeks refuge on remote Selkie Island in the wilds of the Irish Sea with her husband Daniel and their baby daughter Kitty. Hidden away in Daniel’s old family home, Claire hopes to be as cut off from her guilt as she is from the mainland, but can she find peace in a place so full of its own secrets? Twenty years earlier, Daniel’s parents left the island in a boat and never made it to the mainland.

It’s the hottest day of the 1976 heatwave and there’s not a breath of fresh air in the labour ward at Lincoln County Hospital. Michelle is having her fourth child, a girl, while beloved husband Dean is sipping a cold pint in the pub. Their little house is already bursting at the seams, but Michelle is sure they’ll find a way to stretch their budget and continue life as a blissfully chaotic happy family. They name their new baby Donna.

Sen Anon is assigned to be a witness for the Department of Transition, recording the changes in the environment as the world begins to rewild. Abandoned by her mother in a cabin somewhere in upstate New York, Sen will observe the monumental ecological shift known as the Great Transition, the final step in Project Afterworld. Around her drones buzz, cameras watch, microphones listen, digitizing her every move. Privately she keeps a journal of her observations, which are then uploaded and saved, joining the rest of humanity on Maia, a new virtual home.

The only mortal in a family of gods, Medusa is the youngest of the Gorgon sisters. Unlike her siblings, Medusa grows older, experiences change, feels weakness. Her mortal lifespan gives her an urgency that her family will never know.

Kurt Argento, an ex-Detroit street cop who can’t let injustice go—and who has the fighting skills to back up his idealism. If he sees a young girl being dragged into an alley, he's going to rescue her and cause some damage. When he does just that in a small corrupt Missouri town, he’s brutally beaten and thrown into a maximum-security prison. Julie Wakefield, a grad student who happens to be the governor's daughter, is about to take a tour of the prison. But when a malfunction in the security system releases a horde of prisoners, a fierce struggle for survival ensues.

How fast can charity fundraiser CeCe Barclay’s unimpeachable society life come tumbling down? One minute she’s speaking before Chicago’s glitterati. The next, her financier husband is wanted for embezzlement. Her assets seized and her fall mortifyingly public, CeCe grasps for refuge—and employment—as a sorority housemom at Eli Whitney University, her daughter Hayden’s alma mater.