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The Peptide Podcast

The Peptide Podcast

Auteur(s): The Peptide Queen
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 The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited. Entraînement physique et mise en forme Hygiene & Healthy Living Mise en forme, régime et nutrition Médecine alternative
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  • Thymosin Alpha 1, Chronic Fatigue and Lyme Disease

    Thymosin Alpha 1, Chronic Fatigue and Lyme Disease
    Jul 3 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re going to talk about thymosin alpa 1, what it is, how it works, and why some doctors are using it to help those with Lyme disease What Is Thymosin Alpha 1? Let’s start with the basics. Now we’ve talked about thymosin alpha 1 before in the context of immune health, but as a quick refresher, Thymosin alpha 1, or Tα1, is a peptide — a small chain of amino acids — that occurs naturally in the body. It was first isolated from the thymus gland, which is an important immune organ responsible for developing and regulating T cells, especially during childhood. T cells are a type of white blood cell that play a central role in the immune system by identifying and destroying infected or abnormal cells and coordinating immune responses. Over time, our thymus shrinks and our immune response tends to slow down — which may partly explain why chronic infections or immune dysregulation become more common with age. Thymosin alpha 1 acts like an immune system coach — it doesn’t directly kill pathogens, but it enhances the immune system’s ability to detect and fight infections. In fact, it’s made a big impact around the world. Since its discovery in the 1970s, it’s been used in over 35 countries to help treat conditions like hepatitis B and C, certain cancers, and even sepsis. During the COVID-19 pandemic, researchers explored its potential to calm immune overreactions and improve patient outcomes. It’s also popular in veterinary medicine for helping dogs with chronic infections. Plus, some doctors are now investigating its role in boosting vaccine effectiveness and supporting people with autoimmune diseases or age-related immune decline — making thymosin alpha 1 a real immune multitasker. Thymosin Alpha 1 and Lyme Disease So why are doctors using thymosin alpha 1 in Lyme disease? Well, for many people, Lyme can become a long, drawn-out illness. And while antibiotics are usually the first-line treatment, some patients don’t recover fully — instead, they develop lingering symptoms like fatigue, brain fog, joint pain, or neurological issues. This condition is known as Post-Treatment Lyme Disease Syndrome, or PTLDS — and we’ll dive deeper into that in just a minute. In Lyme patients, Thymosin alpha 1 is being used off-label to: Rebalance the immune system Enhance the activity of T cells and natural killer cells Calm overactive inflammation Reduce the intensity and frequency of flare-ups or immune crashes Doctors report that patients using thymosin alpha 1 often feel more resilient — with improved energy, mental clarity, and fewer immune complications — especially in cases involving co-infections like Babesia, Bartonella, or Epstein-Barr virus. What Is PTLDS? Now let’s dig into what happens after Lyme disease treatment for some patients. Post-Treatment Lyme Disease Syndrome, or PTLDS, affects roughly 5 to 20 percent of people who have been treated for Lyme disease. Even after completing a full course of antibiotics, they continue to experience significant symptoms that can last for months — or even years. Some of the most common symptoms of PTLDS include: Chronic fatigue that doesn’t improve with rest Brain fog, poor memory, or difficulty concentrating (sometimes called 'Lyme brain') Joint and muscle pain Sleep disturbances Numbness, tingling, or burning sensations (peripheral neuropathy) Depression, anxiety, or mood swings Sensitivity to light, sound, or smells Dizziness or balance issues And often, fluctuating or cyclical symptoms — where you feel better for a while, then suddenly crash These symptoms can be disabling, and they’re often not reflected in standard lab tests, which can make patients feel dismissed or misdiagnosed. Why Does PTLDS Happen? Researchers are still working to understand why PTLDS happens, but here are some of the leading theories: Immune system dysregulation – The infection may trigger a chronic inflammatory state that lingers long after the bacteria are gone. Persistent infection – Some believe the bacteria can go into a low-metabolic or dormant state, evading antibiotics and reactivating later. Tissue damage – Nerve and joint tissues may have been injured and take a long time to heal. Autoimmune activation – The body may start attacking its own tissues after the infection — similar to what happens in rheumatic fever. Undiagnosed co-infections – Other pathogens like Bartonella or Babesia may still be active and complicate recovery. This is where thymosin alpha 1 may offer a new path — not as a cure, but as a modulator that can help restore immune balance and reduce inflammatory damage. Thymosin Alpha 1 Risk Factors and Who Should Avoid It ...
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    8 min
  • What to Expect on GLP-1 Medications

    What to Expect on GLP-1 Medications
    Jun 26 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re diving into a topic that’s been everywhere lately: GLP-1 medications like semaglutide and tirzepatide for weight loss. You may know them by names like Wegovy, Ozempic, Mounjaro, or Zepbound. I want to give you a clear, realistic picture of what to expect—because while the media loves to highlight the dramatic before-and-after photos, the real journey can be slower and more nuanced for some. So in this episode, we’re going to talk about the truth—what these medications can do, what they can’t, how long things really take, and what you need to know to set yourself up for success. Not hype, not magic promises—just real, honest insight to help you understand the process. Let’s get into it. How GLP-1 & GIP/GLP-1 Agonists Work So first things first—how do these meds work? Semaglutide is a GLP-1 receptor agonist, and tirzepatide is a dual GIP and GLP-1 receptor agonist. Basically, they mimic natural hormones in your body that help regulate blood sugar, slow digestion, and—most importantly for weight loss—reduce appetite and improve satiety. That means you feel fuller faster and stay full longer. You're not obsessing over food like before. And that’s powerful. But—and this is a big one— these peptides don't magically erase years of weight gain overnight. What they do is help make weight loss easier by reducing hunger and supporting your metabolism—but they don't do all the work for you. It’s important to remember they're a powerful tool, not a replacement for your efforts. You're still in control of your choices, habits, and long-term success. Why We Titrate the Dose—and What "Therapeutic Dose" Means Now, let’s talk about dosing. When you start Wegovy, you don’t start at the highest dose. It’s gradually increased over several weeks to give your body time to adjust and to help reduce side effects like nausea or stomach upset. The usual schedule looks like this: You’ll start with 0.25 mg once a week for the first month. Then it increases every four weeks—0.5 mg, then 1 mg, then 1.7 mg. By week 17, most people reach the full dose of 2.4 mg once a week—that’s the dose shown in studies to lead to the most consistent weight loss, with many people losing around 15% of their total body weight over about a year. But here’s the thing—not everyone follows this path exactly, and that’s okay. Some people need to slow down or stay longer at a lower dose if they’re having side effects. Others may need to increase sooner if they’re not seeing appetite changes and are tolerating the medication well. And even though 2.4 mg is considered the “therapeutic dose,” not everyone needs to reach it. Some people feel great and lose weight at a lower dose—and if that’s you, that’s your sweet spot. The real goal is to find the lowest effective dose that controls your hunger, helps you lose weight at a steady pace, and keeps side effects to a minimum. This isn’t a one-size-fits-all journey, and pushing through side effects just to hit the max dose isn’t necessary—or safe. Your best dose is the one your body handles well and helps you make progress. *How Much Weight Can You Expect to Lose—and How Fast? Let’s take a look at the clinical studies. In large trials, people on semaglutide lost about 15% of their total body weight over 68 weeks. For tirzepatide, it was even higher—20% or more in some cases. But here’s the thing—those results happened over a year to a year and a half. Not 6 weeks. Not 3 months. It’s a marathon, not a sprint. Also, most of the weight loss doesn't happen during the titration phase. You may see some weight loss early on, especially if your appetite plummets. But the bulk of the weight loss happens once you reach and maintain your therapeutic dose. Why Everyone’s Journey Looks Different I can’t stress this enough—everybody’s journey is different. Some people feel zero hunger from their very first injection. Others don’t notice a big change until week 10 or 12. Some drop 10 pounds in the first month. Others lose two pounds and feel discouraged. All of those experiences are normal. Your age, hormones, medications, stress levels, sleep, and past diet history? They all play a role. And let’s be real—gaining 20, 50, or 100 pounds didn’t happen in a few weeks, right? It likely took months or even years of lifestyle habits, hormonal shifts, emotional eating, or underlying conditions. So we have to give ourselves that same grace and patience when we’re trying to take the weight off—even with medical support. Navigating Side Effects and Setbacks Let’s talk about the side effects. Nausea, constipation, acid reflux, bloating—yeah, these are pretty common ...
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    11 min
  • 5-Amino-1MQ

    5-Amino-1MQ
    Jun 19 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today, we’re taking a close look at 5-Amino-1MQ—a compound gaining attention for its potential to improve fat loss, metabolic health, and longevity. We’ll break down how it works, the science behind it, and what that could mean for your health. Let’s get started. So, What Is 5-Amino-1MQ? Now, just to clear something up—5-Amino-1MQ isn’t actually a peptide. A lot of people assume it is because it's often talked about alongside peptides like semaglutide or BPC-157, but it's actually a small molecule compound. Its full name is 5-Amino-1-methyl-quino-linium—yeah, a bit of a mouthful—and it's designed to block an enzyme called NNMT. By doing that, it helps keep more NAD⁺ available in your cells, which is a big deal for energy production and metabolic health. It was originally developed in the world of metabolic research. Scientists were exploring ways to improve insulin sensitivity and reduce fat accumulation—especially the dangerous kind, visceral fat. So, while it plays in the same space as peptides when it comes to benefits—like fat loss, energy, and longevity—it’s a totally different kind of compound. Think of it more like a targeted metabolic activator than a signaling peptide. Before we move on, I want to talk about visceral fat for a bit. Visceral fat is the fat that builds up deep inside your abdomen, around your internal organs like your liver, pancreas, and intestines. It’s different from the fat you can pinch under your skin—like on your belly or thighs. That’s called subcutaneous fat. Now, why is visceral fat a problem? Because it’s metabolically active, which means it doesn’t just sit there—it releases hormones and inflammatory chemicals that can mess with your body’s systems. High levels of visceral fat are linked to things like insulin resistance, high cholesterol, high blood pressure, and a greater risk of type 2 diabetes, heart disease, and even certain cancers. So even if someone looks slim on the outside, having too much visceral fat on the inside can still be dangerous for their health. *What Is NNMT and Why Do We Want to Block It? Let’s Talk About The Science. NNMT stands for nicotinamide N-methyltransferase. This enzyme tends to be more active in people who are overweight or have metabolic issues. When that happens, it uses up a lot of something called NAD⁺—a compound your cells need to create energy, especially in the mitochondria, which are like the power plants of your cells. So when NNMT levels go up, here’s what tends to happen: You end up with less NAD⁺, your metabolism slows down, your body stores more fat, and your cells just don’t have the same energy or resilience. That’s where 5-Amino-1MQ comes in. It blocks NNMT, helping your cells hold onto more NAD⁺—and that changes everything. The Metabolic Benefits of Blocking NNMT *So what happens when you increase NAD⁺ inside your cells? Well, in studies—especially in animal models—5-Amino-1MQ led to: Fat breakdown and reduced fat accumulation Improved insulin sensitivity A 30% drop in cholesterol levels And get this—mice lost 5% of their body weight in just 11 days, without changes to diet or exercise. And here’s the kicker—no signs of toxicity or behavioral changes. No weird side effects. Just better metabolic function. Muscle Preservation & Longevity Pathways *One of the most promising things about 5-Amino-1MQ goes beyond fat loss—it’s what it could mean for preserving muscle. Blocking NNMT might actually help you keep your muscle while you’re losing fat. That’s a big deal—especially if you’ve ever tried to drop weight and felt like you were losing strength along with it. This is important because most weight loss methods cause you to lose both fat and muscle, which can slow your metabolism and reduce strength. Preserving muscle while burning fat helps you maintain energy, performance, and long-term metabolic health. There’s also some solid evidence it can boost muscle performance and endurance, which tracks when you think about how it raises NAD⁺. And because NAD⁺ is involved in things like cell repair, mitochondrial function, and longevity pathways like sirtuin activation, you’re not just burning fat—you’re potentially supporting healthy aging and helping your body work more efficiently overall. Oral vs Injectable 5-Amino-1MQ: What’s the Difference? People often ask me, “Should I take 5-Amino-1MQ as a pill or go with injections?” Here’s the deal, the injectable version gets into your system faster and starts working a bit quicker. On the other hand, the oral version takes a little longer to kick in, but it’s way more convenient—just take a capsule and you’re good. ...
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    6 min

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