Épisodes

  • Best Foods While on a GLP-1

    Best Foods While on a GLP-1
    Jul 4 2024
    When embarking on a weight loss journey, it's important to be aware that losing weight can sometimes result in the loss of muscle mass along with fat. This unintended muscle loss can lead to decreased strength, slower metabolism, a less toned appearance, or extra skin. To counteract this, it's essential to incorporate foods that support muscle maintenance and growth into your diet. Consuming adequate protein, healthy fats, and nutrient-dense carbohydrates can help preserve muscle mass, ensuring that your weight loss is both healthy and sustainable. In this podcast, we’ll discuss what foods are best to help maintain muscle mass while taking a GLP-1 agonist like semaglutide or tirzepatide. How does weight loss affect muscle mass? Weight loss can affect muscle mass in several ways, depending on how the weight loss is achieved: Caloric Deficit: Weight loss typically requires a caloric deficit, meaning you consume fewer calories than your body needs to maintain its current weight. If the deficit is too large or if protein intake is insufficient, the body may start to break down muscle tissue for energy, leading to a loss of muscle mass. Exercise: Incorporating strength training or resistance exercises during weight loss can help preserve and even build muscle mass. Conversely, focusing solely on cardio without any form of resistance training may lead to a higher proportion of muscle loss. Protein Intake: As we mentioned, adequate protein intake is important for preserving muscle mass during weight loss. Protein provides the necessary building blocks (amino acids) for muscle repair and growth. Insufficient protein can lead to muscle catabolism, where muscle tissue is broken down. Rate of Weight Loss: Rapid weight loss often results in a higher percentage of muscle loss compared to slower, more gradual weight loss. A slower rate of weight loss allows the body to better preserve muscle tissue while losing fat. To minimize muscle loss during weight loss, it's important to: Include resistance training in your exercise routine Consume adequate protein Avoid excessively large caloric deficits Aim for a gradual and sustainable rate of weight loss What foods help maintain muscle mass while losing weight on a GLP-1? Remember that this discussion doesn’t include all foods that can help support muscle maintenance and growth but it’s a good start. Chicken breast: It’s high in quality protein (22 grams per serving) and leucine. Chicken breast is also low in calories, which can help you lose weight. Try removing the chicken skin to help lower the amount of saturated fat. Fish (Salmon, Tuna): Fish is a great source of protein and omega-3 fatty acids, which have anti-inflammatory effects and support muscle recovery. Studies also show that omega-3 fatty acids can help reduce muscle soreness. One serving of salmon provides about 20 grams of protein while one serving of fresh tuna provides about 28 grams of protein. Eggs: A complete protein source that contains all essential amino acids, as well as vitamins and minerals like vitamin D and leucine (amino acid), which support muscle function. Eggs are often called the “perfect protein”. One large hard-boiled egg provides about 6 grams of protein. Greek Yogurt: High in protein and often lower in sugar than regular yogurt, Greek yogurt also provides probiotics that support digestive health. Like eggs, Greek yogurt provides all essential amino acids. Pro tip: Keep in mind that Greek yogurt is better than plain yogurt as it provides nearly double the amount of protein (17 grams per serving) that plain yogurt provides in the same portion size. If you’re watching carbohydrate intake, Greek yogurt has about half as much as regular yogurt. Also, plain Greek yogurt is better than flavored Greek yogurt. This is because flavored yogurt has added sugar. Low-fat cottage cheese (2% milk fat): Another dairy product high in protein and also contains casein, a slow-digesting protein that’s beneficial for muscle maintenance during periods of fasting (such as overnight) and weight loss. There are about 30 grams of protein in one serving of low-fat cottage cheese. Legumes (Lentils, Chickpeas): Plant-based sources of protein, fiber, and micronutrients like iron and magnesium, which support muscle function and recovery. Nuts and Seeds: Rich in healthy fats, protein, and micronutrients like vitamin E , iron, and magnesium. Baru nuts and almonds are high in fiber and polyphenols that help your body recover from strenuous exercise. Each provides about that out 7 grams of protein per serving. Tofu and Edamame: Plant-based sources of protein also provide phytoestrogens and minerals like calcium, which are beneficial for lean muscle growth. One serving of firm tofu provides about 11 grams of protein while cooked edamame provides about 18 grams of protein. Quinoa: A whole grain that is also a complete protein like eggs and Greek yogurt. Quinoa provides ...
    Voir plus Voir moins
    9 min
  • Digestion and the Impact of GLP-1 Agonists

    Digestion and the Impact of GLP-1 Agonists
    Jun 27 2024
    Digestion is a complex process that involves breaking down food into nutrients that the body can absorb and use. For a healthy person, the time it takes to digest meals and snacks can vary based on the type and composition of the food consumed. Keep in mind the digestive process varies significantly between healthy individuals and those with digestive disorders. While healthy individuals typically digest meals within a predictable timeframe, digestive disorders can cause delays or speed up this process. Keep in mind that GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) influence digestion by slowing gastric emptying and regulating appetite, which can be beneficial for weight loss and diabetes management but may pose challenges for those with certain digestive conditions. In this podcast, we’ll discuss how digestion is impacted by digestive orders and how GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) affect digestion. The Digestive Process Explained Starting in the Mouth: The digestive process begins in the mouth when you chew food. Chewing breaks down food into smaller particles, and saliva, which contains an enzyme that starts the digestion of starches, moistens the food, making it easier to move along the gastrointestinal (GI) tract. Moving to the Esophagus: When you swallow, food travels down the esophagus. Here, peristalsis—rhythmic contractions—automatically propel the food forward. At the lower end of the esophagus, a circular muscle called the lower esophageal sphincter (LES) relaxes to allow food to pass into the stomach and then closes to prevent stomach acid from flowing back into the esophagus. Stomach Function: Once food reaches the stomach, muscles in the stomach wall mix it with stomach acid and enzymes, creating digestive juices that break the food down into a liquid mixture called chyme. The Small Intestine: In the small intestine, food mixes with digestive juices from the pancreas, liver, and gallbladder. The walls of the small intestine then absorb nutrients into the bloodstream before peristalsis moves the remaining mixture forward. Large Intestine Function: Undigested food, fluids, and damaged cells from the GI tract's lining enter the large intestine or colon. Here, water is absorbed, transforming the waste material from liquid to stool. Peristalsis then moves the stool into the rectum, where it is stored until it is expelled during a bowel movement. Typical Digestion Times: Liquids: Water and other clear fluids pass through the stomach quickly, usually within 20-30 minutes. Simple Carbohydrates: Foods like fruit, white bread, and sugary snacks are typically digested within 30-60 minutes. Complex Carbohydrates: Whole grains, quinoa, vegetables, and legumes take longer, around 2-3 hours. Proteins: Meat, dairy, and other high-protein foods generally take 3-4 hours to digest. Fats: Fatty foods such as nuts, cheese, and fried foods are the slowest to digest, often taking up to 6 hours or more. On average, the entire digestive process, from ingestion to elimination, can take about 24-72 hours in healthy individuals. Digestion in Individuals with Digestive Disorders Digestive disorders can significantly alter the time it takes for food to move through the digestive system. Conditions such as gastroparesis, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) can disrupt normal digestive function. Gastroparesis: This condition, often caused by diabetes or other underlying issues, slows stomach emptying. Symptoms include nausea, vomiting, and bloating. In gastroparesis, digestion can be severely delayed, with food remaining in the stomach for prolonged periods, sometimes up to several hours longer than normal. Irritable Bowel Syndrome (IBS): IBS can cause both accelerated and delayed digestion, depending on whether diarrhea-predominant (IBS-D) or constipation-predominant (IBS-C) symptoms are present. IBS-D can lead to faster transit times, while IBS-C can slow digestion, causing significant delays in the passage of food. Inflammatory Bowel Disease (IBD): Conditions such as Crohn's disease and ulcerative colitis involve chronic inflammation of the gastrointestinal tract, which can disrupt normal digestion. Depending on the severity and location of inflammation, digestion can be faster or delayed. What is the Impact of GLP-1 Agonists on Digestion? GLP-1 (glucagon-like peptide-1) agonists, such as semaglutide (Wegovy) and tirzepatide (Zepbound), are medications primarily used for managing type 2 diabetes and obesity. These drugs mimic the action of the GLP-1 hormone, which plays an important role in regulating appetite, insulin secretion, and gastric motility. Slowed Gastric Emptying: GLP-1 agonists slow the rate at which food leaves the stomach. This effect can help increase feelings of fullness and reduce overall food intake, contributing to weight loss. In healthy individuals, this slowed gastric emptying can extend...
    Voir plus Voir moins
    10 min
  • Resistance Training to improve Peptide Performance

    Resistance Training to improve Peptide Performance
    Jun 20 2024
    Did you know that you don't need a gym to enjoy the benefits of resistance training? You can do it right in the comfort of your home with no gym equipment, and it's fantastic for your overall health and heart health. Regular resistance training can improve your blood pressure, blood sugar, blood lipids, and body composition. It's especially helpful for older adults and those with a higher risk of heart problems (e.g., high blood pressure or cholesterol, diabetes, excess weight, current or former smokers, or a family history of heart disease). In this podcast, we’ll discuss simple home workouts that you can do to help your overall health. What is resistance training? Resistance training, also known as strength training, involves exercises that improve muscular strength and endurance. This form of exercise typically uses resistance in the form of weights, resistance bands, or body weight to work specific muscle groups. By repeatedly challenging muscles, resistance training enhances their ability to generate force and sustain physical activity. Benefits of Resistance Training Cardiovascular and Overall Health While resistance training primarily targets muscle strength and endurance, it also offers substantial cardiovascular benefits. Regular resistance training can: Improve heart health by reducing blood pressure and cholesterol levels. Help keep your arteries flexible and improves blood vessel function while lowering inflammation levels that typically lead to atherosclerosis (clogged arteries). Keep in mind that while you may not notice these cardiovascular effects, you may experience noticeable improvements in your sleep and mood. Weight Loss and Muscle Mass Resistance training is a powerful tool for weight loss and muscle mass maintenance. But how? Increased Metabolism: Building muscle boosts your resting metabolic rate, meaning you burn more calories even at rest. Fat Loss: While you may not see immediate weight loss, resistance training can help you lose fat and gain lean muscle, leading to a healthier body composition. Muscle Preservation: During weight loss, preserving muscle mass is crucial. When people lose weight, they usually lose fat along with muscle mass. Given the popularity of GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound), it’s important to know that muscle wasting is a possible side effect of these medications. Resistance training ensures that most of the weight lost comes from fat, not muscle. Keep in mind: Resistance training also promotes better body mechanics and posture, reducing the risk of injury and improving balance and coordination. How to Get Started with Resistance Training Getting started with resistance training can be intimidating, especially if you already don’t exercise or have mobility limitations due to arthritis, neurological conditions like multiple sclerosis, or obesity. You can always join a gym and meet with a personal trainer but we all know this is both costly and time-consuming. While in-person classes or training sessions might be motivating and fun, there is always the option of trying resistance training at home, on your own. You can find free exercise videos on YouTube or personal fitness blogs. Set Clear Goals: Determine what you want to achieve, whether it’s building muscle, losing or maintaining weight, or improving overall health. Start with a Plan: Create a balanced workout plan that includes all major muscle groups (e.g., chest, shoulders, upper back, back and front of arms and legs, stomach, and lower back). Learn Proper Technique: Proper form is important to prevent injuries. Consider working with a trainer initially or using reputable online resources. Start Light: To master the exercises, begin with lighter weights, then gradually increase the resistance as you become more comfortable and stronger. Start with shorter, lower-intensity sessions to help your body readjust and minimize the risk of injury. Consistency: Consistency is key. Aim for at least two resistance training sessions per week. Each session should last 15 to 20 minutes and focus on 8 to 10 different exercises. Examples of Resistance Training Exercises Here are some common resistance training exercises: Air squats, wall squats, and lunges: Target the legs and glutes. Specifically the front and back thigh and buttocks. No equipment is needed. Deadlifts or upright rows engage the upper back muscles. Both can be done using long resistance bands instead of weights. Chest Press: This exercise works the chest, shoulders, and triceps. It can also be done without weights by doing push-ups, incline push-ups, or decline push-ups. Planks or abdominal crunch: Improve core strength and stability. No equipment is needed. Bicep Curls: Target the front upper arm. Again, if you don’t have weights at home, you can perform bicep curls using resistance bands. Calf raises: These target the calf muscle, and no gym equipment is needed. They...
    Voir plus Voir moins
    7 min
  • The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation

    The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation
    Jun 13 2024
    Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases. In this podcast, we’ll discuss GLP-1’s role in reducing inflammation and how it may help you. What is GLP-1? GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. Here's how glucose-dependent insulin secretion works: Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels. Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1). Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin. Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy. Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels). GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells. The Link Between GLP-1 and Inflammation Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. How does GLP-1 reduce inflammation? Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response. Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body. Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor. Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles. Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs have demonstrated neuroprotective effects by reducing neuroinflammation, improving neuronal survival, and enhancing cognitive function. These benefits are attributed to the reduction in pro-inflammatory cytokines and the enhancement of neurotrophic factors. Therapeutic Implications The anti-inflammatory properties of GLP-1 have significant therapeutic implications. GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, are now being explored for their potential in treating various inflammatory and chronic diseases. Type 2 Diabetes and Metabolic Syndrome: The dual action of GLP-1 in regulating blood glucose and reducing inflammation makes it a promising therapeutic agent for managing type 2 diabetes and its complications. Cardiovascular Diseases: Given the role of inflammation in atherosclerosis and other cardiovascular conditions, GLP-1 analogs could offer cardiovascular protection and improve outcomes in patients with heart disease. Neurodegenerative Disorders: The ...
    Voir plus Voir moins
    7 min
  • Differences Among Popular GLP-1 Receptor Agonists for Type 2 Diabetes

    Differences Among Popular GLP-1 Receptor Agonists for Type 2 Diabetes
    Jun 6 2024
    A class of medications known as GLP-1 receptor agonists has revolutionized the treatment of type 2 diabetes and obesity. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion and inhibits glucagon release, helping to regulate blood sugar levels and promote weight loss. In this podcast, we’ll talk about the differences among some of the most well-known GLP-1 receptor agonists for type 2 diabetes. Ozempic (Semaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Primarily for type 2 diabetes (lower blood sugar and A1c); also approved for reducing the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease. Keep in mind, Wegovy (semaglutide) is a higher-dose version that’s approved for weight loss. When you start taking Wegovy or Ozempic, you’ll begin with a low dosage. Your prescriber will increase your dosage every four weeks until you reach the target amount. However, the specific dosage you inject will differ depending on the medication. The maximum dose for Ozempic is 2mg weekly, while the target dose for Wegovy is 2.4mg weekly. Rybelsus (Semaglutide) Form: Oral tablet Dosing Frequency: Once daily Uses: Lower blood sugar and A1c in people with type 2 diabetes. Rybelsus shares the same active ingredient as the injectable medications Ozempic and Wegovy. Ozempic is also approved for Type 2 diabetes, while Wegovy is approved specifically for weight loss. Rybelsus is available in three different strengths: 3 mg, 7 mg, and 14 mg. Similar to Ozempic, the dose is slowly increased every 4 weeks. Good to know: It's important to take Rybelsus first thing in the morning with 4 oz of water. After taking it, you should wait at least 30 minutes before eating, drinking, or taking other medications. Failing to do so may reduce its effectiveness. Currently, Rybelsus is undergoing clinical trials to evaluate its effectiveness for weight loss. The trials involve higher doses than those approved for diabetes treatment. Results indicate that a 50 mg dose of oral semaglutide (Rybelsus) achieves weight loss comparable to Wegovy. Trulicity (Dulaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes; and like Ozempic, it’s also approved for reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Like Ozempic and Rybelsus, you will start at a low dose to help reduce side effects. Your healthcare provider will then gradually increase the dose, balancing the management of side effects with the benefits of blood sugar control. The maximum dose for Trulicity is 4.5mg weekly. Victoza (Liraglutide) Form: Injectable Dosing Frequency: Once daily Uses: Type 2 diabetes; also approved to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Victoza is one of three GLP-1 agonists approved for treating Type 2 diabetes in children aged 10 and older. The other options are Trulicity (dulaglutide) and Bydureon BCise (exenatide). More on this later. Ozempic, however, is only approved for use in adults. Saxenda and Victoza are both injectable medications containing liraglutide, but they are approved for different uses. Saxenda is FDA-approved for chronic weight management in people 12 and older, while Victoza is approved for treating Type 2 diabetes in people 10 and older. Victoza also helps lower the risk of major adverse cardiovascular events in adults with diabetes and heart disease. Both medications are injected once a day, starting with a low dose that is gradually increased over time. The target dose for Saxenda is 3 mg once daily, whereas the maximum dose for Victoza is 1.8 mg once daily. Byetta (Exenatide) Form: Injectable Dosing Frequency: Twice daily Uses: Type 2 diabetes. Additional Benefits: It has a shorter duration of action than other GLP-1 agonists, which may be preferable for some patients. Byetta, approved in 2005, was the first GLP-1 medication of its kind for diabetes. Its active ingredient, exenatide, is a synthetic version of a substance found in Gila monster saliva. The recommended starting dose for Byetta is 5 mcg twice daily, administered within 60 minutes before your morning and evening meals. After one month, your healthcare provider may increase the dose to 10 mcg twice daily. Starting at a lower dose helps reduce stomach-related side effects. Bydureon BCise (Exenatide Extended-Release) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes. Additional Benefits: Extended-release formulation provides a more convenient dosing schedule compared to Byetta. Unlike Byetta, Bydureon BCise has a fixed dose of 2 mg administered once weekly, on the same day each week. It can be taken at any time of day, with or without food. Mounjaro (Tirzepatide) Form: Injectable Dosing Frequency: Once weekly ...
    Voir plus Voir moins
    10 min
  • Peptide Therapy to Get Rid of Age Spots

    Peptide Therapy to Get Rid of Age Spots
    May 30 2024
    As you age, you might notice dark or brown spots (hyperpigmentation) appearing on your face, arms, or the tops of your hands. These age spots can also develop on your legs, back, and other parts of your body. Age spots on the face (cheek, chin, nose, forehead, and upper lip) are typically caused by years of exposure to ultraviolet light from the sun (melasma). These age spots are more common in women and those who are pregnant or taking birth control pills. While experts don't know exactly why this is, it's thought that hormones play a role in melasma. Keep in mind that age spots can also be caused by skin injury, such as a cut, burn, or acne breakout. They can also be caused by inflammation, certain medications, and medical conditions such as hypothyroidism, Addison's disease, and certain vitamin deficiencies (B12 or folate). While you can't go back in time to apply more sunscreen and prevent age spots, there are peptide therapies that you can use to fade them. As a refresher, peptides are short chains of amino acids. When used topically, they can penetrate the skin and signal cells to perform specific functions, such as collagen production, skin repair, and pigment regulation. In this podcast, we'll talk about how peptide therapy works to help get rid of the appearance of age spots and what you can expect: How Does Peptide Therapy Work for Age Spots? Inhibition of Melanin Production: Certain peptides can inhibit the activity of tyrosinase, an enzyme crucial for the synthesis of melanin (a dark brown pigment). These peptides help lighten dark spots and even out skin tone by reducing melanin production. Promotion of Skin Renewal: Peptides can stimulate skin cell turnover, promoting the shedding of pigmented cells and the generation of new, healthier skin cells. This helps in fading dark spots over time. Anti-Inflammatory Effects: Peptides can reduce inflammation, which often contributes to hyperpigmentation, especially in conditions like post-inflammatory hyperpigmentation (PIH). Antioxidant Properties: Some peptides have antioxidant properties, protecting the skin from oxidative stress and damage caused by UV radiation, which can exacerbate dark spots. What are Some Common Peptides Used for Treating Dark Spots? Copper Peptides: Known for their wound healing and anti-inflammatory properties, copper peptides can help improve skin texture and reduce pigmentation. Palmitoyl Tetrapeptide-7: This peptide reduces inflammation and promotes the regeneration of new skin cells, helping to diminish dark spots over time. Oligopeptide-68: Specifically designed to reduce hyperpigmentation by inhibiting melanin production and evening out skin tone. Decapeptide-12: Effective in reducing pigmentation and improving overall skin brightness. What are the Benefits of Peptide Therapy for Dark Spots? Targeted Action: Peptides can be formulated to specifically target pigmentation pathways, offering a more precise approach compared to general skin-lightening agents. Minimal Side Effects: Peptides are generally well-tolerated, with a lower risk of irritation and side effects than more aggressive treatments like chemical peels or laser therapy. Multi-functional Benefits: In addition to lightening dark spots, peptides often provide additional skin benefits such as improved texture, firmness, and hydration. Application and Usage of Peptides for Age Spots Topical Serums and Creams: Peptides are commonly found in serums and creams. These should be applied as directed, typically once or twice daily, after cleansing and before moisturizing. Consistency is Key: Peptide therapy results can take several weeks to become noticeable. Consistent use is crucial for achieving the best results. Sun Protection: Peptides used to treat dark spots should be paired with effective sun protection. Sunscreen helps prevent further pigmentation and supports the action of peptides. As a general rule, make sure to choose sunscreen that is broad-spectrum (protects against UVA and UVB rays), SPF 30 (or higher), and water-resistant. If you are considering peptide therapy for dark spots, it's recommended to consult with a dermatologist to determine the most suitable peptides for your skin type and condition. Often, combining adequate sunscreen, prescription medications, peptide therapy, and certain procedures such as microdermabrasion, lasers, and chemical peels may be needed. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by ...
    Voir plus Voir moins
    6 min
  • Injectable BPC-157 vs Oral BPC-157

    Injectable BPC-157 vs Oral BPC-157
    May 23 2024
    BPC-157 (body protection complex) is a peptide consisting of 15 amino acids. It’s become popular in recent years for its potential therapeutic benefits, particularly in tissue repair and inflammation reduction. BPC-157 is derived from a protein found in the human stomach. It promotes healing in a variety of health conditions, from muscle and tendon injuries to gut health and brain fog. BPC-157 is available as an oral pill or an injection into the fatty tissue (subcutaneous injection). In this podcast, we’ll discuss the differences between these two dosage forms and which may be better for you. Injectable BPC-157 Absorption and Bioavailability Injectable BPC-157 can be injected subcutaneously (under the skin) or intramuscularly (into the muscle). Injections ensure that the peptide bypasses the digestive system, allowing for direct entry into the bloodstream. As a result, the peptide's bioavailability is significantly higher with injections. Bioavailability refers to the proportion of a medication/peptide that enters the circulation and is able to have an active effect. Effectiveness Injectable BPC-157 is often seen as a better choice for healing injuries like torn ligaments and tendons, muscle tears, and joint damage. Injections can be given close to the injury site, which might help it heal faster. Dosage and Administration The dosage for injectable BPC-157 typically ranges from 400 to 600 micrograms per day for up to 12 weeks, followed by a one-month break. The BPC-157 dose and length of treatment depend on the severity of the condition and the individual’s response. Remember: Using injectable medication requires careful handling. You need to keep everything clean to avoid infections and use the right technique to ensure the peptide's effectiveness. Pros and Cons Pros: High bioavailability and potency Direct application to target areas Faster onset of therapeutic effects Cons: Requires needles and sterile conditions Potential discomfort or pain at injection sites More complex administration compared to oral forms Oral BPC-157 Absorption and Bioavailability Oral BPC-157 is taken in capsule or tablet form and digested in the gastrointestinal tract before entering the bloodstream. This route of administration can result in lower bioavailability due to the peptide being broken down by digestive enzymes and stomach acid. However, many people who use oral BPC-157 argue that it still retains sufficient bioactivity to be effective, particularly for gastrointestinal conditions. Effectiveness Oral BPC-157 is often chosen for its convenience and potential benefits for digestive health. Since it directly interacts with the gastrointestinal lining, it may be more effective for treating issues such as inflammatory bowel disease (IBD), ulcers, and leaky gut syndrome. It also helps to restore the gut microbiome. While systemic effects (e.g., muscle or tendon healing) might be less pronounced compared to injections, oral administration still provides therapeutic benefits, albeit possibly at a slower rate. Dosage and Administration The dosage for oral BPC-157 generally ranges from 500 to 1000 micrograms per day, reflecting its lower bioavailability. The exact dosage can vary based on individual needs and the condition being treated. Oral BPC-157 is easy to administer, making it more user-friendly for those uncomfortable with injections. Pros and Cons Pros: Easy and painless administration Suitable for gastrointestinal issues No need for sterile conditions or needles Cons: Lower bioavailability compared to injections Possibly slower therapeutic effects for non-gastrointestinal conditions Less targeted delivery Choosing Between Injectable and Oral BPC-157 The choice between injectable and oral BPC-157 depends largely on the specific condition being treated, the desired speed of recovery, and personal preferences regarding administration. For Acute and Targeted Injuries: Injectable BPC-157 is generally preferred for its higher potency and faster results. Athletes and individuals with significant muscle, tendon, or ligament injuries might benefit more from injections. For Gastrointestinal Health: Oral BPC-157 may be more effective due to its direct interaction with the digestive tract. It is also more convenient for daily use and suitable for individuals who are averse to injections. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their ...
    Voir plus Voir moins
    6 min
  • AHK-Cu for Skin Health, Collagen Synthesis, and Hair Growth

    AHK-Cu for Skin Health, Collagen Synthesis, and Hair Growth
    May 20 2024
    AHK-Cu, also known as Copper Tripeptide-1, has garnered significant attention in dermatology and cosmetology for its many benefits. The cosmeceutical industry has studied it extensively in animal and lab models. This short peptide, consisting of the amino acids alanine, histidine, and lysine chemically bound to a copper ion, plays a crucial role in skin health, collagen synthesis, and hair growth. In this podcast, we’ll examine how AHK-Cu works and its potential side effects. How does it work? AHK-Cu works in many ways to help with skin health, collagen synthesis, and hair growth. Skin Health: AHK-Cu can increase VEGF (vascular endothelial growth factor) levels. VEGF is a protein found in the body that can make new blood cells when your body needs them. By increasing VEGF levels, AHK-Cu can activate fibroblasts and endothelial cells. This is a good thing because fibroblasts produce collagen and elastin, two molecules that help with skin tone, texture, and flexibility. Endothelial cells line blood vessels and help with blood vessel health and growth. Increased levels of fibroblasts and endothelial cells help improve wound healing and decrease fine lines and wrinkles. Collagen Synthesis: Collagen is a vital protein that provides structural support to the skin, maintaining its firmness and elasticity. As we mentioned, AHK-Cu boosts collagen synthesis by activating fibroblasts, the cells responsible for producing collagen. The copper ion in AHK-Cu is essential for the cross-linking of collagen and elastin fibers, which helps maintain the skin’s structural integrity and reduces the appearance of fine lines and wrinkles. Also, keep in mind that collagen attracts water. This is important because when water enters the skin, it hydrates the cells of the extracellular matrix, which helps reduce the appearance of lines and wrinkles. Hair Growth: AHK-Cu promotes hair growth in two ways. First, it encourages the growth of blood vessels by stimulating the secretion of VEGF. This is important because blood vessels are needed to supply nutrients to the hair follicles. AHK-Cu also decreases dihydrotestosterone (DHT), the hormone that’s involved in male pattern baldness and thinning hair for both men and women as they age. What are the potential benefits of AHK-Cu? Improved Skin Appearance: Regular use of AHK-Cu can significantly improve skin texture, tone, and overall appearance. It helps reduce signs of aging, such as wrinkles and fine lines and enhances skin firmness and elasticity. Promotes Wound Healing: AHK-Cu accelerates wound and scar healing by promoting cellular repair and reducing inflammation. This makes it an effective ingredient in post-procedure skincare products and treatments for conditions like acne scars. Hair Growth: For individuals experiencing hair thinning or hair loss, AHK-Cu can be a valuable addition to their hair care regimen. It promotes thicker, healthier hair by stimulating the hair follicles and prolonging the hair growth phase. Keep an eye out for these AHK-Cu side effects. While AHK-Cu is generally considered safe and well-tolerated, it is important to be aware of potential side effects: Skin Irritation: Some individuals may experience mild skin irritation, redness, or itching when using products containing AHK-Cu, especially if they have sensitive skin or are using it for the first time. Allergic Reactions: Although rare, allergic reactions to AHK-Cu can occur. Symptoms may include rash, itching, hives, and trouble breathing. To rule out allergic reactions, a patch test should be performed before using a new product containing AHK-Cu. Discoloration: Due to its copper content, AHK-Cu can cause temporary blue or green skin discoloration in some cases. This is typically harmless and fades with continued use or once the product is washed off. Proper use of AHK-Cu can significantly enhance skin vitality and hair density, offering a natural and effective solution to common cosmetic concerns. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. WHAT TO LISTEN TO NEXT: Losing hair? Hair loss may be preventable. Listen to the hair growth and peptide therapy podcast. Want healthier skin and hair? Learn about copper peptides for skin and hair health. GLP-1’s and hair loss: Hair loss isn’t directly caused by GLP-1’s. Listen to find out what causes hair loss when ...
    Voir plus Voir moins
    6 min