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This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.

Lawrence M. Friedman is Professor of Law at Stanford University and author of 23 books about law and legal history. Hailed as American law's greatest living historian, Friedman traces the evolution of America's legal system from the colonial period to the present. A Modern Library Chronicle, this book is concise, insightful, and graced with wit.

The legal system in America is the basis of freedom as we know it today. The system is based, ultimately, on the common law of England, but it has grown, developed, and changed over the years. American law has been a critical factor in American life since colonial times. It has played a role in shaping society, but society - the structure, culture, economy, and politics of the country - has decisively shaped the law. Through history, the legal system has been intimately involved with every major issue in American life.