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Edinburgh, 1850. Despite being at the forefront of modern medicine, hordes of patients are dying all across the city, with doctors finding their remedies powerless. But it is not just the deaths that dismay the esteemed Dr James Simpson - a whispering campaign seeks to blame him for the death of a patient in suspicious circumstances. Simpson's protégé Will Raven and former housemaid Sarah Fisher are determined to clear their patron's name.

Edinburgh, 1849. Hordes of patients are dying all across the city, with doctors finding their remedies powerless. And a whispering campaign seeks to paint Dr. James Simpson, pioneer of medical chloroform, as a murderer. Determined to clear Simpson’s name, his protégé Will Raven and former housemaid Sarah Fisher must plunge into Edinburgh’s deadliest streets and find out who or what is behind the deaths. Soon they discover that the cause of the deaths has evaded detection purely because it is so unthinkable.