Biology Genetics

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type - from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope....

James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, and agricultural chemistry as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact on our society and our world.

But the quest to unravel life's genesis is not just a story of big ideas. It is also a compelling human story, rich in personalities, conflicts, and surprising twists and turns. Along the way the journey takes in some of the greatest discoveries in modern biology, from evolution and cells to DNA and life's family tree. It is also a search whose end may finally be in sight. In The Genesis Quest, Michael Marshall shows how the quest to understand life's beginning is also a journey to discover the true nature of life, and by extension our place in the universe.

Since the conclusion of the Human Genome Project in 2003, scientists have been racing toward a grand goal: offering individuals a decoding of their complete genetic makeup for just $1,000. As Kevin Davies reveals in this exquisitely reported account, the $1,000 genome will be a reality by 2011 and it will usher in a whole new era of personalized, genomic medicine.

In Hurricane Lizards and Plastic Squid, biologist Thor Hanson tells the remarkable story of how plants and animals are responding to climate change: adjusting, evolving, and sometimes dying out. Anole lizards have grown larger toe pads, to grip more tightly in frequent hurricanes. Warm waters cause the development of Humboldt squid to alter so dramatically that fishermen mistake them for different species. Brown pelicans move north, and long-spined sea urchins south, to find cooler homes.

A natural history of the wilderness in our homes, from the microbes in our showers to the crickets in our basements Even when the floors are sparkling clean and the house seems silent, our domestic domain is wild beyond imagination. In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone.

"It's the animal in us," we often hear when we've been bad. But why not when we're good? Primates and Philosophers tackles this question by exploring the biological foundations of one of humanity's most valued traits: morality.In this provocative book, primatologist Frans de Waal argues that modern-day evolutionary biology takes far too dim a view of the natural world, emphasizing our "selfish" genes.

How did humans come to be who we are? In his marvelous, eccentric, and widely lauded book Being a Beast, legal scholar, veterinary surgeon, and naturalist extraordinaire Charles Foster set out to understand the consciousness of animal species by living as a badger, otter, fox, deer, and swift. Now, he inhabits three crucial periods of human development to understand the consciousness of perhaps the strangest animal of all—the human being.

In this intriguing book, evolutionary biologist Scott Solomon draws on the explosion of discoveries in recent years to examine the future evolution of our species. Combining knowledge of our past with current trends, Solomon offers convincing evidence that evolutionary forces still affect us today. But how will modernization - including longer lifespans, changing diets, global travel, and widespread use of medicine and contraceptives - affect our evolutionary future?

Asserting that religious creeds and philosophical questions can be reduced to purely genetic and evolutionary components, and that the human body and mind have a physical base obedient to the laws of physics and chemistry, Genesis demonstrates that the only way for us to fully understand human behavior is to study the evolutionary histories of nonhuman species. Of these, Wilson demonstrates that at least 17 - among them the African naked mole rat and the sponge-dwelling shrimp - have been found to have advanced societies based on altruism and cooperation.

How did life begin? It is perhaps the most important question science has ever asked. Over the centuries, the search for an answer has been entwined with some of science's most revolutionary advances, including van Leeuwenhoek's microscope, Darwin's theory of evolution, and Crick and Watson's unveiling of DNA.

Seventy years ago, Erwin Schrdinger posed a simple, yet profound, question: What is life?. How could the very existence of such extraordinary chemical systems be understood? This problem has puzzled biologists and physical scientists both before, and ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology?

A giant of archaeology, Colin Renfrew has immeasurably improved our understanding of human history. In this passionately argued work, he offers a concise summary of prehistory - human existence that predates the development of written records - while challenging the very definition of prehistory itself.

Pets have never been more popular. Over half of American households share their home with either a cat or a dog, and many contain both. This is a huge change from only a century ago, when the majority of domestic cats and dogs were working animals, keeping rodents at bay, guarding property, herding sheep. Nowadays, most are valued solely for the companionship they provide. As mankind becomes progressively more urban and detached from nature, we seem to be clinging to the animals that served us well in the past.

With all the advances in science in the last century, why are there still so many infectious diseases? Why haven’t we found cures for difficult cancers? Why hasn’t any major progress been made in the treatment of mental illness? And how do we intend to stop, and not only that but reverse, global warming and the climate crisis? In Saved by Science, scientist Mark Poznansky examines the many crises facing humanity while encouraging us with the promise of an emerging solution: synthetic biology.

In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies - far from the out-of-control nightmare depicted in science fiction - have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.

Our species has amassed unprecedented knowledge of nature, which we have tried to use to seize control of life and bend the planet to our will. In A Natural History of the Future, biologist Rob Dunn argues that such efforts are futile. We may see ourselves as life’s overlords, but we are instead at its mercy. In the evolution of antibiotic resistance, the power of natural selection to create biodiversity, and even the surprising life of the London Underground, Dunn finds laws of life that no human activity can annul.

It seems likely that scientists will someday discover how life can emerge on habitable planets like the early Earth and Mars. In Origin of Life: What Everyone Needs to Know, David W. Deamer has written a comprehensive guide to the origin of life that is organized in three sections.

Horses have a story to tell - one of resilience, sociability, and intelligence and of partnership with human beings. In The Horse, journalist and equestrienne Wendy Williams brings that story brilliantly to life. Williams chronicles the 56-million-year journey of horses as she visits with experts around the world, exploring what our biological affinities and differences can tell us about the bond between horses and humans and what our longtime companions might think and feel.

When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves.