Health Care History

Inflammation is the body’s ancestral response to its greatest threats: injury and foreign microbes. But as the threats we face have evolved, new science reveals simmering inflammation underneath the surface of everything from heart disease and cancer to mysterious autoimmune conditions. In A Silent Fire, gastroenterologist Shilpa Ravella takes us on a lyrical quest across time, around the world, and into the body to reveal hidden inflammation at the root of modern disease―and how we can control it.

As America’s favorite frontline Covid-19 health journalist, Dr. Sanjay Gupta has barely left his primetime seat in his makeshift studio basement since the pandemic began (other than to perform brain surgery). He’s had insider access to the drama’s unfolding, including exclusive conversations with the world’s top public health experts and behind-the-scenes scientists racing to find treatments and cures.

In 1953, a 27-year-old factory worker named Henry Molaison - who suffered from severe epilepsy - received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next 60 years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.

From the 15th to the mid-19th centuries, scurvy caused more deaths at sea than storms, shipwrecks, combat, and all other diseases combined. The cure for scurvy ranks among the greatest of military successes, yet its impact on history has mostly been ignored. In this book, Stephen R. Brown delivers a lively recounting of how three determined individuals overcame the constraints of 18th century thinking to solve the greatest medical mystery of their era. Brimming with tales of ships, sailors, and bureaucracy, Brown presents a vivid picture of life aboard the ship during the age of sail.

In 1959, a Cincinnati pharmaceutical firm, the William S. Merrell Company, quietly began distributing samples of an exciting new wonder drug already popular around the world. Touted as a sedative without risks, thalidomide was handed out freely, under the guise of clinical trials, by doctors who believed approval by the Food and Drug Administration was imminent. But in 1960, when the application for thalidomide landed on the desk of FDA medical reviewer Frances Kelsey, she quickly grew suspicious.

In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. Sixteen million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their 70s and 80s, the number of patients will rise to an estimated 13.8 million by 2025. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis.

Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history. With the identification of AIDS in the early 1980s, another chapter was added to this chronicle of events, which William McNeill explores in his introduction to this edition. McNeill’s highly acclaimed work is a brilliant and challenging account of the effects of disease on human history. His sophisticated analysis and detailed grasp of the subject make this book fascinating to listen to.

Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity’s uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality.

In early 2020, the world was on edge. An ominous virus was spreading on different continents, and no one knew what the coming weeks would bring. Far from the hot spots, the cruise ship Zaandam, owned by Holland America, was preparing to sail from Buenos Aires, Argentina, loaded with 1,200 passengers—Americans, Europeans and South Americans, plus 600 crew. Within days, people aboard begin to fall sick. With only two doctors aboard and few medical supplies to test for or treat COVID-19, and with dwindling food and water, the ship wanders the oceans on an unthinkable journey.

The harrowing, dramatic and profoundly moving story of the Australian and New Zealand nurses who served in the Great War. Now a major six-part television series. By the end of the Great War, 45 Australian and New Zealand nurses had died on overseas service and over 200 had been decorated. These were the women who left for war looking for adventure and romance but were soon confronted with challenges for which their civilian lives could never have prepared them.

Control is a book about what geneticist Adam Rutherford calls “a defining idea of the twentieth century.” Inspired by Darwin’s ideas about evolution, eugenics arose in Victorian England as a theory for improving the British population, and quickly spread to America. With disarming wit and scientific precision, Rutherford explains why eugenics still figures prominently in the twenty-first century, despite its genocidal past. And he confronts insidious recurring questions, revealing the intellectual bankruptcy of the idea, and the scientific impossibility of its realization.

Oxford Case Histories in Infection and Microbiology contains over 45 well structured cases, providing comprehensive coverage of the diagnostic and management dilemmas in clinical microbiology and infectious diseases. Each case comprises of a brief patient history with relevant clinical examination findings, thus insuring the listener is aware of how to confirm a diagnosis rapidly, with reference throughout to laboratory techniques, advice on therapy, epidemiological features, and areas which can be controversial.

For much of recorded history, people considered the heart to be the most important organ in the body. In cultures around the world, the heart—not the brain—was believed to be the location of intelligence, memory, emotion, and the soul. Over time, views on the purpose of the heart have transformed. Modern medicine and science dismissed what was once the king of the organs as a mere blood pump subservient to the brain, yet the heart remains a potent symbol of love and health and an important part of our cultural iconography.

Interweaving history, original reportage, and personal narrative, Pandemic explores the origin of epidemics, drawing parallels between the story of cholera - one of history's most disruptive and deadly pathogens - and the new pathogens that stalk humankind today, from Ebola and avian influenza to drug-resistant superbugs.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.

Sigmund Freud revolutionized the way in which we think about ourselves. From its beginnings as a theory of neurosis Freud developed psychoanalysis into a general psychology, which became widely accepted as the predominant mode of discussing personality and interpersonal relationships. Anthony Storr goes one step further and investigates the status of Freud's legacy today and the disputes that surround it.

Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be "conquered" ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.

The "absorbing and powerful" (Wall Street Journal) story of two pioneering suffragette doctors who shattered social expectations and transformed modern medicine during World War I. In No Man's Land, Wendy Moore illuminates this turbulent moment of global war and pandemic when women were, for the first time, allowed to operate on men. Their fortitude and brilliance serve as powerful reminders of what women can achieve against all odds.

For centuries, medicine has made reckless use of one of earth's most toxic substances: mercury - and the consequences, often invisible or ignored, continue to be tragic. Today, global emissions of mercury as well as other toxicants, make us all more vulnerable to its effects. From the worst cases of syphilis to Sigmund Freud's first cases of hysteria, from baffling new disorders in 19th century Britain to the modern scourge of autism, The Age of Autism traces the long overlooked history of mercury poisoning.

Rabies enjoys a fearsome and lurid reputation. Throughout the decades of spiraling growth that defined New York City from the 1840s to the 1910s, the bone-chilling cry of "Mad dog!" possessed the power to upend the ordinary routines and rhythms of urban life. In Mad Dogs and Other New Yorkers, Jessica Wang examines the history of this rare but dreaded affliction during a time of rapid urbanization.