History Medicine Science

One in ten American adults tried intermittent fasting last year, and they may be on to something. The latest research shows that fasting repairs cellular damage, improves the outcomes for chemotherapy patients, and helps with keeping a healthy weight, leading to a resurgence in recent years. Journalist Steve Hendricks’s The Oldest Cure in the World tells the history of fasting—from the ancient world (Jesus treated an epileptic with fasting) to its rediscovery centuries later.

When three-month-old Lia Lee arrived at the county hospital emergency room in Merced, California, a chain of events was set in motion from which neither she nor her parents nor her doctors would ever recover. Lia's parents, Foua and Nao Kao, were part of a large Hmong community in Merced, refugees from the CIA-run "Quiet War" in Laos.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

Now published in five languages, Strange Medicine casts a gimlet eye on the practice of medicine through the ages that highlights the most dubious ideas, bizarre treatments, and biggest blunders. From bad science and oafish behavior to stomach-turning procedures that hurt more than helped, Strange Medicine presents strange but true facts and an honor roll of doctors, scientists, and dreamers who inadvertently turned the clock of medicine backward.

Pandora's Lab takes us from opium's heyday as the pain reliever of choice to recognition of opioids as a major cause of death in the United States; from the rise of trans fats as the golden ingredient for tastier, cheaper food to the heart disease epidemic that followed; and from the cries to ban DDT for the sake of the environment to an epidemic-level rise in world malaria.

Based on the film by acclaimed documentary filmmaker Ken Burns, The Mayo Clinic: Faith, Hope, Science chronicles the history of this unique organization, from its roots as an unlikely partnership between a country doctor and a Franciscan order of nuns to its position today as a worldwide model for patient care, research, and education. The book demonstrates how the institution’s remarkable 150-year history continues to inspire the way medicine is practiced there today.

In the winter of 1918, at the height of World War I, history's most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in 24 weeks than AIDS has killed in 24 years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision between modern science and epidemic disease.

At the University of Wisconsin, Dr. Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.

James A. Garfield may have been the most extraordinary man ever elected president. Born into abject poverty, he rose to become a wunderkind scholar, a Civil War hero, and a renowned and admired reformist congressman. Nominated for president against his will, he engaged in a fierce battle with the corrupt political establishment. But four months after his inauguration, a deranged office seeker tracked Garfield down and shot him in the back. But the shot didn’t kill Garfield. The drama of what hap­pened subsequently is a powerful story of a nation in tur­moil.

Twenty years ago the most common cause of death for medical humanitarians and other aid workers was traffic accidents; today it is violent attacks. And the death of each doctor, nurse, paramedic, midwife, and vaccinator is multiplied untold times in the vulnerable populations deprived of their care. In a 2005 report, the ICRC found that for every soldier killed in the war in the Democratic Republic of the Congo, more than 60 civilians died due to loss of immunizations and other basic health services.

A History of the World in Six Plagues shows that throughout history, outbreaks of disease have been exacerbated by and gone on to further expand the racial, economic, and sociopolitical divides we allow to fester in times of good health. Princeton-trained historian Edna Bonhomme’s examination of humanity’s disastrous treatment of pandemic disease takes us across place and time from Port-au-Prince to Tanzania, and from plantation-era America to our modern COVID-19-scarred world to unravel shocking truths about the patterns of discrimination in the face of disease.

The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.

The story of poison is the story of power. For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family's spoons, tried on their underpants, and tested their chamber pots. Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions.

In Medical Bondage, Cooper Owens examines a wide range of scientific literature and less formal communications in which gynecologists created and disseminated medical fictions about their patients, such as their belief that black enslaved women could withstand pain better than white "ladies". Even as they were advancing medicine, these doctors were legitimizing, for decades to come, groundless theories related to whiteness and blackness, men and women, and the inferiority of other races or nationalities.

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.

In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. Sixteen million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their 70s and 80s, the number of patients will rise to an estimated 13.8 million by 2025. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis.

In The Poisoner's Handbook, Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime.

The most fatal virus known to science, rabies kills nearly 100 percent of its victims once the infection takes root in the brain. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh, fascinating, and often wildly entertaining look at one of mankind’s oldest and most fearsome foes.

The first major bioterror event in the United States - the anthrax attacks in October 2001 - was a clarion call for scientists who work with "hot" agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a number-one New York Times best seller, Richard Preston takes us into the heart of USAMRIID, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland.