Medical History

In 1953, a 27-year-old factory worker named Henry Molaison - who suffered from severe epilepsy - received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next 60 years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.

Intensive care units and mechanical ventilation are the crucial foundation of modern medical care: without them, the appalling death toll of the COVID-19 pandemic would be even higher. In The Autumn Ghost, Dr. Hannah Wunsch traces the origins of these two innovations back to a polio epidemic in the autumn of 1952. Drawing together testimony from doctors, nurses, medical students, and patients, Wunsch relates a gripping tale of an epidemic that changed the world.

It's the winter of 1967, and snow is on the ground in the colorful Irish village of Ballybucklebo, but the chilly weather can't stop love from warming hearts all over the county. Not just the love between a man and woman, as with young doctor Barry Laverty and his fiancée, Sue Nolan, who are making plans to start a new life together, but also the love of an ailing pensioner for a faithful dog that's gone missing, the love of the local gentry for the great estate they are on the verge of losing, or Dr. Fingal Flahertie O'Reilly's love for his longtime home and practice.

Larry Brilliant's life journey has led him on a purposeful path across continents and countercultural movements, marching arm in arm with the men and women who defined a generation. A man who has always been in the right place at the right time, Brilliant has engaged with some of the most prominent thought leaders, spiritual masters, heroes, and icons in the world, including Neem Karoli Baba (Maharajji), Martin Luther King Jr., Steve Jobs, Mikhail Gorbachev, Wavy Gravy, the Grateful Dead, the Dalai Lama, and Barack Obama.

Every medical decision - whether to have chemotherapy, an X-ray, or surgery - is a risk, no matter which way you choose. In You Bet Your Life, physician Paul A. Offit argues that, from the first blood transfusions 400 years ago to the hunt for a COVID-19 vaccine, risk has been essential to the discovery of new treatments. More importantly, understanding the risks is crucial to whether, as a society or as individuals, we accept them.

Caroline Crampton’s life was upended at the age of seventeen, when she was diagnosed with Hodgkin’s lymphoma, a relatively rare blood cancer. After years of invasive treatment, she was finally given the all clear. But being cured of the cancer didn’t mean she felt well. Instead, the fear lingered, and she found herself always on the alert, braced for signs that the illness had reemerged.

Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity’s uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality.

In the last half of the twentieth century, Don Thomas discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the deadliest illnesses. His feats were extraordinary, earning him a Nobel Prize, and the cascade of treatments he inspired have reshaped and will continue to reshape the practice of clinical medicine. Yet no one has ever written Thomas’s courageous story.Dr. Frederick R. Appelbaum, a member of Thomas’s research team, does so for the first time.

Martin A. Lee traces the dramatic social history of marijuana, from its origins to its emergence in the 1960s as a defining force in a culture war that has never ceased. Lee describes how the illicit marijuana subculture overcame government opposition and morphed into a dynamic, multibillion-dollar industry. Colorful, illuminating, and at times irreverent, this is a fascinating listen for recreational users and patients, students and doctors, musicians and accountants, Baby Boomers and their kids, and anyone who has ever wondered about the secret life of this ubiquitous herb.

Just as polio loomed over the 1950s and AIDS stalked the 1980s and 1990s, post-traumatic stress disorder haunts us in the early years of the 21st century. Over a decade into the United States' "global war on terror", PTSD afflicts as many as 30 percent of the conflict's veterans. But the disorder's reach extends far beyond the armed forces. In total, some 27 million Americans are believed to be PTSD survivors. Yet to many of us, the disorder remains shrouded in mystery, secrecy, and shame.

On January 12, 2010, a major earthquake struck near Port-au-Prince, Haiti. Hundreds of thousands of people died, and the greater part of the capital was demolished. Dr. Paul Farmer, U.N. deputy special envoy to Haiti, who had worked in the country for nearly thirty years treating infectious diseases like tuberculosis and AIDS, and former President Bill Clinton, the U.N. special envoy to Haiti, had just begun to work on an extensive development plan to improve living conditions in Haiti.

For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As cardiologist and best-selling author Sandeep Jauhar tells in The Heart, it was only recently that we demolished age-old taboos and devised the transformative procedures that changed the way we live. Deftly alternating between historical episodes and his own work, Jauhar tells the colorful and little known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ.

Country of Ash is the starkly compelling, original chronicle of a Jewish doctor who miraculously survived near-certain death, first inside the Lodz and Warsaw ghettoes, where he was forced to treat the Gestapo, then on the Aryan side of Warsaw, where he hid under numerous disguises. He clandestinely recorded the terrible events he witnessed, but his manuscript disappeared during the Warsaw Ghetto Uprising. After the war, reunited with his wife and young daughter, he rewrote his story.

It wasn’t supposed to be this hard. If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting 50 years of false starts, abysmal failures, and miraculous triumphs.

Galen of Pergamum (A.D. 129-ca. 216) began his remarkable career tending to wounded gladiators in provincial Asia Minor. Later in life he achieved great distinction as one of a small circle of court physicians to the family of Emperor Marcus Aurelius, at the very heart of Roman society. Susan Mattern's The Prince of Medicine offers the first authoritative biography in English of this brilliant, audacious, and profoundly influential figure.

In Out Cold, science writer Phil Jaekl chronicles the underappreciated story of human innovation with cold, from Ancient Egypt, where it was used to treat skin irritations, to 18th-century London, where scientists used it in their first explorations of suspended animation. Throughout history, physicians have used cold to innovate life extension, enable distant space missions, and explore consciousness.

In January 1918, as World War I raged on, a new and terrifying virus began to spread across the globe. In three successive waves, from 1918 to 1919, influenza killed more than 50 million people. German soldiers termed it Blitzkatarrh, British soldiers referred to it as Flanders Grippe, but worldwide, the pandemic gained the notorious title of “Spanish flu”. Nowhere on earth escaped: the United States recorded 550,000 deaths (five times its total military fatalities in the war) while European deaths totaled more than two million.

G. Wayne Miller has dramatically and meticulously reconstructed an amazing true story: how a group of renegade Minnesota surgeons, led by Dr. Walt Lillehei, made medical history by becoming the first doctors to operate deep inside the human heart.

In the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages.

Hal Rosenbluth, the maverick executive behind Take Care Health Systems, former president of Walgreens Health and Wellness and now chairman and CEO of New Ocean Health Solutions, offers an unfiltered exposé of his 227 medical claims in just two years—exposing the underbelly that illness anxiety may be costing the average sufferer and the health system as a whole. Hypochondria is a bold exploration and a call to action to address the broader impact that each stakeholder—health plans, providers, health systems and big pharma—have on the nation’s overstressed health-care system.