Medical Technology

"Are you one of us?" a patient once asked Marsha Linehan, the world-renowned psychologist who developed dialectical behavior therapy. "Because if you were, it would give all of us so much hope." Over the years, DBT had saved the lives of countless people fighting depression and suicidal thoughts, but Linehan had never revealed that her pioneering work was inspired by her own desperate struggles as a young woman. Only when she received this question did she finally decide to tell her story.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

In My Stroke of Insight, Taylor shares her unique perspective on the brain and its capacity for recovery, and the sense of omniscient understanding she gained from this unusual and inspiring voyage out of the abyss of a wounded brain. It would take eight years for Taylor to heal completely. Because of her knowledge of how the brain works, her respect for the cells composing her human form, and most of all an amazing mother, Taylor completely repaired her mind and recalibrated her understanding of the world.

A 23-year veteran of emergency medical services, paramedic Matthew Sias took a detour in his career to pursue the death-care business and found a complementarity between two seemingly divergent careers. Silent Siren: Memoirs of a Life Saving Mortician is the record of some of the more memorable calls he has responded to through the years.

When Jenna Blake starts her freshman year at Somerset University, she's not only living on her own for the first time, she's moving closer to the father she never really knew. It's an exciting time, filled with new faces and new challenges, not to mention parties and boys and … corpses? Jenna is torn about her future. She'd like to be a doctor like her mother, but she can't stand the sight of blood. Her father, a criminology professor, thinks he has the answer—and sends her to interview for a job with the Medical Examiner—an interview that takes place in the middle of an autopsy!

Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their 12 children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the 10 Galvin boys, one after another, were diagnosed as schizophrenic.

Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.

Just two months before the September 11 terrorist attacks, Dr. Judy Melinek began her training as a New York City forensic pathologist. With her husband and their toddler holding down the home front, Judy threw herself into the fascinating world of death investigation-performing autopsies, investigating death scenes, and counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking listeners behind the police tape of some of the most harrowing deaths in the Big Apple.

Kristine Barnett’s son Jacob has an IQ higher than Einstein’s, a photographic memory, and he taught himself calculus in two weeks. At 9 he started working on an original theory in astrophysics that experts believe may someday put him in line for a Nobel Prize, and at age 12 he became a paid researcher in quantum physics. But the story of Kristine’s journey with Jake is all the more remarkable because his extraordinary mind was almost lost to autism. At age 2, when Jake was diagnosed, Kristine was told he might never be able to tie his own shoes.

In 1949, Ron Losee, a young Yale Medical School graduate, headed west with his wife and small daughter to begin the practice of medicine. They settled in Ennis, Montana, in a log cabin that also became their office and lab. Patients made themselves at home in the living room. One small bag held all their medical equipment. It was a proud moment when a patient first called Losee "Doc." His fee on that occasion was three dollars.

Just months ago, millions of people were stunned by ChatGPT's amazing abilities–and its bizarre hallucinations. But that was 2022. GPT-4 is now here, with smarter, more accurate, and deeper technical knowledge. GPT-4 and its competitors and followers are on the verge of transforming medicine. But with lives on the line, you need to understand these technologies–stat.

What can death teach us about life? Conducting many thousands of post-mortems has given Dr Richard Shepherd the opportunity to examine death at every stage of life. Each autopsy is its own unique investigation, providing evidence of how, through life, the risks to us ebb and flow. From old to young, from murder to misadventure and from illness to accidental death, each body has taught him something: about human development, about mortality, about its owner's life story, about justice and even about himself.

The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.

On October 13, 1972, a Uruguayan Air Force plane carrying members of the "Old Christians" rugby team - and many of their friends and family members - crashed into the Andes Mountains. I Had to Survive offers a gripping and heartrending recollection of the harrowing, brink-of-death experience that propelled survivor Roberto Canessa to become one of the world's leading pediatric cardiologists.

Jeanne Marie Laskas first met the young forensic pathologist Dr. Bennet Omalu in 2009, while reporting a story for GQ that would go on to inspire the movie Concussion. Omalu told her about a day in September 2002, when, in a dingy morgue in downtown Pittsburgh, he picked up a scalpel and made a discovery that would rattle America in ways he’d never intended. Omalu was new to America, chasing the dream, a deeply spiritual man escaping the wounds of civil war in Nigeria.

From insulin comas and lobotomy to incarceration and exile, Walter Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade's "Lithium Salts in the Treatment of Psychotic Excitement" described, for the first time, lithium's astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide.

Blinded at age three, Mike May defied expectations by breaking world records in downhill speed skiing, joining the CIA, and becoming a successful inventor, entrepreneur, and family man. He had never yearned for vision. Then, in 1999, a chance encounter brought startling news: a revolutionary stem-cell transplant surgery could restore May's vision.

In gripping prose, one of the world's leading cardiac surgeons lays bare both the wonder and the horror of a life spent a heartbeat away from death. When Stephen Westaby witnessed a patient die on the table during open-heart surgery for the first time, he was struck by the quiet, determined way the surgeons walked away. As he soon understood, this detachment is a crucial survival strategy in a profession where death is only a heartbeat away. In Open Heart, Westaby reflects on over 11,000 surgeries, showing us why the procedures have never become routine and will never be.

The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen.

In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases.