It’s 2 AM on a Saturday night in the spring of 2001, and 28-year-old Cecily Gardner sits alone in a dive bar in New York’s East Village, questioning her life. Feeling lonesome and homesick for the Midwest, she wonders if she’ll ever make it as a reporter in the big city - and whether she made a terrible mistake in breaking up with her longtime boyfriend, Matthew.

The Kingsley family is American royalty, beloved for their military heroics, political service, and unmatched elegance. In 1967, after Joseph S. Kingsley, Jr. is killed in a tragic accident, his charismatic son inherits the weight of that legacy. But Joe III is a free spirit—and a little bit reckless. Despite his best intentions, he has trouble meeting the expectations of a nation, as well as those of his exacting mother, Dottie.

Growing up, Josie and Meredith Garland shared a loving, if sometimes contentious, relationship. Josie was impulsive, spirited, and outgoing, Meredith hardworking, thoughtful, and reserved. When tragedy strikes, their delicate bond splinters.

Four freshmen arrive at college from completely different worlds: Lainey, a California party girl with a flair for drama; Tyson, a brilliant scholar and aspiring lawyer from Washington, D.C.; Summer, an ambitious, recruited athlete from the Midwest; and Hannah, a mild-mannered southerner who is content to quietly round out the circle of big personalities. Soon after arriving on campus, they strike up a conversation in their shared dorm, and the seeds of friendship are planted.

Tessa Russo is the mother of two young children and the wife of a renowned pediatric surgeon. Despite her own mother's warnings, Tessa has recently given up her career to focus on her family and the pursuit of domestic happiness. From the outside, she seems destined to live a charmed life. Valerie Anderson is an attorney and single mother to six-year-old Charlie - a boy who has never known his father.

Ellen and Andy's first year of marriage doesn't just seem perfect, it is perfect. There is no question how deep their devotion is, and how naturally they bring out the best in each other. But one fateful afternoon, Ellen runs into Leo for the first time in eight years. Leo, the one who brought out the worst in her. Leo, the one who left her heartbroken with no explanation. Leo, the one she could never quite forget. When his reappearance ignites long-dormant emotions, Ellen begins to question whether the life she's living is the one she's meant to live.

Best friends Lindsey, Kendra, and Dani endure every parent’s nightmare when a tragic accident befalls their teenage boys, leaving one dead, another in a coma, and a third too traumatized to speak. Reeling from the worst night of their lives, the three mothers plunge into a desperate investigation of the bizarre incident. How could something so horrible happen in their wealthy Southern California suburb? They soon discover that the accident was just the beginning, and troubling discoveries lead to chilling questions: Do they really know their children? Do they even know each other?

Laurie is sure love at first sight doesn't exist anywhere but the movies. But then, through a misted-up bus window one snowy December day, she sees a man who she knows instantly is the one. Their eyes meet, there's a moment of pure magic...and then her bus drives away. Certain they're fated to find each other again, Laurie spends a year scanning every bus stop and cafe in London for him. But she doesn't find him, not when it matters anyway. Instead they "reunite" at a Christmas party, when her best friend, Sarah, giddily introduces her new boyfriend: the man from the bus.

It was a mistake to trust him. Shivering and bruised, a teen wakes up on the side of a dirt road with no memory of how she got there—or who she is. The police don’t know where she came from until a frantic man arrives at the station. He’s been searching for her for hours. He has her school ID, her birth certificate, and even family photos.

Marian Caldwell is a 36-year-old television producer, living her dream in New York City. With a fulfilling career and satisfying relationship, she has convinced everyone, including herself, that her life is just as she wants it to be. But one night, Marian answers a knock on the door ... only to find Kirby Rose, an 18-year-old girl with a key to a past that Marian thought she had sealed off forever. From the moment Kirby appears on her doorstep, Marian’s perfectly constructed world - and her very identity - will be shaken to its core.

Laid off from her department store job, Carmen has perilously little cash and few options. The prospect of spending Christmas with her perfect sister Sofia, in Sofia’s perfect house with her perfect children and her perfectly ordered yuppie life, does not appeal. Frankly, Sofia doesn’t exactly want her prickly sister Carmen there, either. But Sofia has yet another baby on the way, a mother desperate to see her daughters get along, and a client who needs help revitalizing his shabby old bookshop. So Carmen moves in and takes the job.

Frederick Fife was born with an extra helping of kindness in his heart. If he borrowed your car, he’d return it washed with a full tank of gas. The problem is there’s nobody left in Fred’s life to borrow from. At eighty-two, he’s desperately lonely, broke, and on the brink of homelessness. But Fred’s luck changes when, in a bizarre case of mistaken identity, he takes the place of grumpy Bernard Greer at the local nursing home. Now he has warm meals in his belly and a roof over his head—as long as his poker face is in better shape than his prostate and that his look-alike never turns up.

Ten years ago he killed my son. Today I married him. Ten years ago my darling son Jesse was murdered and our perfect family was destroyed. My strong, handsome boy, so full of life, became a memory, a photo I carried with me everywhere. But today I’m finally close to finding happiness again. My ash-blonde hair has been curled into ringlets. Carefully placed white flowers frame my delicate features. The small, drab chapel has been prettied up with white satin, and there are tiny red hearts scattered on the small table where I will soon sign the register with my new husband.

Shy and gawky, Ana has always daydreamed about living the life of her exotic half-sister Bee, a pop singer who had a number one hit single before she inexplicably vanished from the celebrity scene. When Bee turns up dead, Ana is dispatched to the big city to clear out her apartment. Instantly seduced by the second-hand glamour of Bee's baubles, bangles, and bottles of Pierre-Jouet, Ana takes up with Bee's wild club-hopping cronies.

Julia White is struggling: her bartending job isn’t cutting it, and her first book has sold hardly any copies. She’s broke, barely able to make ends meet while drowning in her late mother’s medical bills and reeling after a one-night stand with her ex-boyfriend, who’s now completely ghosted her. Enter Johnathan Aster, world-renowned photographer, with a proposal: he has a never-before-seen photograph of a woman falling from a train bridge, clutching what appears to be a baby. And he wants Julia to research the story.