Orphaned during her passage from Ireland, young, white Lavinia arrives on the steps of the kitchen house and is placed, as an indentured servant, under the care of Belle, the master's illegitimate slave daughter. Lavinia learns to cook, clean, and serve food while guided by the quiet strength and love of her new family. In time Lavinia is accepted into the world of the big house, caring for the master's opium-addicted wife and befriending his dangerous yet protective son. She attempts to straddle the worlds of the kitchen and big house, but her skin color will forever set her apart.

Montgomery, Alabama, 1973. Fresh out of nursing school, Civil Townsend intends to make a difference, especially in her African American community. At the Montgomery Family Planning Clinic, she hopes to help women shape their destinies, to make their own choices for their lives and bodies.

Born on a plantation in Charles City, Virginia, Pheby Delores Brown has lived a relatively sheltered life. Shielded by her mother’s position as the estate’s medicine woman and cherished by the Master’s sister, she is set apart from the others on the plantation, belonging to neither world. She’d been promised freedom on her eighteenth birthday, but instead of the idyllic life she imagined with her true love, Essex Henry, Pheby is forced to leave the only home she has ever known. She unexpectedly finds herself thrust into the bowels of slavery at the infamous Devil’s Half Acre.

Moments after Lisbeth is born, she’s taken from her mother and handed over to an enslaved wet nurse, Mattie, a young mother separated from her own infant son in order to care for her tiny charge. Thus begins an intense relationship that will shape both of their lives for decades to come. Though Lisbeth leads a life of privilege, she finds nothing but loneliness in the company of her overwhelmed mother and her distant, slave-owning father.

In 1872, sixteen-year-old Goes First, a Crow Native woman, marries Abe Farwell, a white fur trader. He gives her the name Mary, and they set off on the long trip to his trading post in the Cypress Hills of Saskatchewan, Canada. Along the way, she finds a fast friend in a Métis named Jeannie; makes a lifelong enemy in a wolfer named Stiller; and despite learning a dark secret of Farwell’s past, falls in love with her husband.