It's June in Montreal, and Dr. Temperance Brennan, who has left a shaky marriage back home in North Carolina to take on the challenging assignment of Director of Forensic Anthropology for the province of Quebec, looks forward to a relaxing weekend in beautiful Quebec City. First, though, she must stop at a newly uncovered burial site in the heart of the city. The remains are probably old and only of archeological interest, but Tempe must make sure they're not a case for the police. One look at the decomposed and decapitated corpse, stored neatly in plastic bags, tells her she'll spend the weekend in the crime lab.

He slips into their homes at night and walks silently into bedrooms where women lie sleeping, unaware of the horrors they soon will endure. The precision of the killer's methods suggests he is a deranged man of medicine, propelling the Boston newspapers and the frightened public to name him "The Surgeon". The cops' only clue rests with another surgeon, the victim of a nearly identical crime. Two years ago, Dr. Catherine Cordell fought back and killed her attacker before he could complete his assault.

Assaulted by the bitter cold of a Montreal winter, the American-born Dr. Temperance Breman, Forensic Anthropologist for the Province of Quebec, digs for a corpse where Sister Elisabeth Nicolet, dead over a century and now a candidate for sainthood, should lie in her grave. A strange, small coffin, buried in the recesses of a decaying church, holds the first clue to the cloistered nun's fate.

Tory Brennan, niece of acclaimed forensic anthropologist Temperance Brennan (of the Bones novels and hit TV show), is the leader of a ragtag band of teenage "sci-philes" who live on a secluded island off the coast of South Carolina. When the group rescues a dog caged for medical testing on a nearby island, they are exposed to an experimental strain of canine parvovirus that changes their lives forever.

Four young women have been found murdered—tortured and strangled in their own beds—all victims of the same brilliant monster. Using a skilled hand and the latest technology in forensic medicine, Kay Scarpetta begins the process of gathering the microscopic clues the latest battered body has to give.