Hydra has a synthetic pathogen that will make the entire human race dependent on them for the cure. A.I.M.'s newly developed nanotech compound to enslave humanity is dangerously close to contaminating the world's water supplies. Ultron is poised on the edge of Singularity, Earth's technology at his metallic fingertips. Dormammu has a plan to save the world - by claiming it as his own. The High Evolutionary is rewriting the human genome in a bid to turn humankind into a eugenic slave-race. Everybody wants to rule the world - and only the isolated Avengers can stop them.

Hey, hey, book lovers, take off those big thick glasses - this is Deadpool speaking! Sorry Marvel, somethin' happened to your copy guy. Anyway, this is my first prose novel, and they got this dude Stefan Petrucha to write it. He's good people. He's written novels and comics. But here's the thing: This book is about dogs. Dogs that turn into big nasty monsters. And then I gotta kill 'em. Thing is, I like killing people - the ones that deserve it, anyway - but I won't kill dogs. So that's what we call a character dilemma.

Under secret orders to assassinate the Widow, Hawkeye, the rough-edged marksman, finds himself caught up in a violent prison break that releases some of the world's most vicious and powerful criminals. Defying his superiors, Hawkeye joins forces with the sultry Russian spy and a mismatched group of personalities that include Spider-Man, Spider-Woman, Luke Cage, Captain America, and Iron Man.

The alien shapeshifters called the Chitauri were defeated by the Ultimates in a decisive battle, but suspicious activity leads the Ultimates to believe that not all of the aliens were destroyed in that cataclysmic attack. Stark Industries has developed means of quickly and easily detecting Chitauri DNA, but the federal government refuses to adopt the technology, claiming that if the tech is widely available, the Chitauri will find a way to fool it. Frustrated by the government’s seeming unwillingness to protect its own people, Captain America takes matters into his own hands.

Cyclops and Emma Frost re-form the team with the express purpose of "astonishing" the world. But when breaking news regarding the mutant gene unexpectedly hits the airwaves, will it derail their new plans before they even get started? As demand for the "mutant cure" reaches near-riot levels, the X-Men go head-to-head with the enigmatic Ord, with an unexpected ally - and some unexpected adversaries - tipping the scales!