In AD 2600, the human race is finally beginning to realize its full potential. Hundreds of colonized planets scattered across the galaxy host a multitude of prosperous and wildly diverse cultures. Genetic engineering has pushed evolution far beyond nature's boundaries, defeating disease and producing extraordinary spaceborn creatures. Huge fleets of sentient trader starships thrive on the wealth created by the industrialization of entire star systems, and throughout inhabited space the Confederation Navy keeps the peace.

The year is 2380. The Intersolar Commonwealth, a sphere of stars some 400 light-years in diameter, contains more than 600 worlds, interconnected by a web of transport "tunnels" known as wormholes. At the farthest edge of the Commonwealth, astronomer Dudley Bose observes the impossible: Over 1,000 light-years away, a star...vanishes. It does not go supernova. It does not collapse into a black hole. It simply disappears.

AD 3580. The Intersolar Commonwealth has spread through the galaxy to over a thousand star systems. It is a culture of rich diversity with a place for everyone. A powerful navy protects it from any hostile species that may lurk among the stars. For Commonwealth citizens, even death has been overcome.

In the 1800s, a sailing ship crashes off the coast of Norway. In the 1900s, a Zepellin explores an icy canyon in Antarctica. In the far future, a spaceship sets out for an alien artifact. Each excursion goes horribly wrong. And on every journey, Dr. Silas Coade is the physician, but only Silas seems to realize that these events keep repeating themselves. And it's up to him to figure out why and how. And how to stop it all from happening again.

The year is 3326. Nigel Sheldon, one of the founders of the Commonwealth, receives a visit from the Raiel - self-appointed guardians of the Void, the enigmatic construct at the core of the galaxy that threatens the existence of all that lives. The Raiel convince Nigel to participate in a desperate scheme to infiltrate the Void. Once inside, Nigel discovers that humans are not the only life-forms to have been sucked into the Void. The humans trapped there are afflicted by an alien species of biological mimics.