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Hunger is not one feeling. In Part 2, Dr Federica Amati of ZOE maps appetite as a four-stage system, from the moment you smell food to the fibre still feeding your gut microbes hours later, and shows where GLP-1 drugs act on it. She explains what food noise is and is not, why psychological support belongs alongside these medicines, and how leptin resistance can leave someone feeling starved in a body with plenty of stored energy. We also cover why eating very little can stall weight loss, what a plateau is, and how the next generation of drugs differs from the first.
KEY TOPICS
Full versus satiated: the four stages of appetite (head, stomach, small intestine, colon)
Why the fibre-fed colon stage is the one most of us miss
Why diet culture works against these drugs
Food noise: what it is, and how it differs from loving food
Why psychological support is an essential part of treatment
Leptin resistance and the body's drive to return to its set point
Very low calorie intake, metabolic adaptation and plateaus
Switching between drugs, and why slow increases and decreases in dose matter
Why cycle syncing the dose does not hold up for this group
What makes second and third-generation drugs different
TIMESTAMPS
0:00 Introduction
2:05 Full versus satiated: the four stages of appetite
9:30 Why diet culture works against these drugs
11:40 Food noise, and what it is not
15:00 Why psychological support matters
17:00 Leptin resistance: starving in a body full of energy
21:40 Eating very little, and weight-loss plateaus
24:20 Breaking a plateau, and the lowest effective dose
26:40 Switching between drugs
27:40 Cycle syncing: does it apply here?
30:40 What makes the next generation of drugs different
32:35 Coming up in Part 3
REFERENCES AND RESOURCES MENTIONED
The Appetite Reset, Dr Federica Amati (Penguin Michael Joseph, 2026)
Gut hormones discussed: GLP-1, PYY and GIP
Drugs discussed: Ozempic and Wegovy (semaglutide), Mounjaro (tirzepatide)
GUEST LINKS
Website: https://federicaamati.com
Instagram: https://www.instagram.com/dr.fede.amati/
LinkedIn: https://www.linkedin.com/in/dr-fede-amati/
ZOE: https://zoe.com/en-gb?utm_medium=press&utm_source=website&utm_campaign=UK_app
ZOE Daily30: https://zoe.com/en-gb/daily30?utm_medium=press&utm_source=daily30&utm_campaign=UK_daily30
This episode is for educational purposes only and is not medical advice. GLP-1 medications should only be used under qualified medical supervision. If you are considering starting, stopping or changing one, speak to a doctor who knows your full medical history.
Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com